Mannitol is an osmotic diuretic commonly used to reduce intracranial pressure. While various side-effects, including hyperosmolar states, precipitate reduction in intracranial pressure, rebound phenomenon and hypervolaemia have been described, hypotension due to rapid administration has not been widely recognised.
CotéC.J., GreenhowD.E., MarshallB.E.The Hypotensive response to rapid administration of hypertonic solutions in man and in the rabbit. Anesthesiology1979; 50: 30–35.
