Plasma bupivacaine concentrations were measured in 45 children, whose ages ranged from 4 months to 12 years, following administration of caudal epidural analgesia. Using 3 mg/kg of bupivacaine 0.25%, mean blood levels of 1.2-1.4 μg/ml were reached, which are well within the limits of projected toxic levels. Simultaneous arterial and venous sampling showed a small but significant difference between these two sampling sites for the first fifteen minutes.
BishopW., OppenheimR.C., EyresR.Analysis of lignocaine and bupivacaine in plasma by high performance liquid chromatography. Asian J Pharmaceut Sci1980; 2: 91.
4.
MooreD.C., MatherL.E., BridenbaughL.D.Bupivacaine: an evaluation of its tissue and systemic toxicity in humans. Acta Anaesth Scand1977; 21: 109.
5.
MooreD.C., MatherL.E., BridenbaughP.O.Arterial and venous plasma levels of bupivacaine following epidural and intercostal nerve blocks. Anesthesiology1976; 45: 39.
6.
JorfeldtL., LofstromB., PernowB., PerssonB., WahrenJ., WidmanB.The effect of local anaesthetics on central circulation and respiration in man and dog. Acta Anaesth Scand1968; 12: 153.
7.
ScottD.B.Evaluation of clinical tolerance of local anaesthetic agents. Br J Anaesth1975; 47: 328.
