No significant changes were found in packed cell volume, haemoglobin concentration and red cell glutathione levels in patients before and after anaesthesia with halothane or enflurane. These results, though unable to explain the mechanism, support the earlier suggestion that glutathione plays little, if any, role in protecting liver against toxic effects of these anaesthetic agents or their metabolites.
OyamaT., TakaguchiM.Plasma levels of ACTH and Cortisol in man during halothane anaesthesia and surgery. Anaesth Analg1970; 49: 363.
2.
CarstensenH., Amer1, WideL., AmerB.Plasma testosterone, LH and FSH during the first 24 hours after surgical operations. J Steroid Biochem1973; 4: 605.
3.
OyamaT., ShibataS., MatsukiA., KudoT.Serum endogenous thyroxine levels in man during anaesthesia and surgery. Br J Anaesth1969; 41: 103.
4.
DawsonB., AdsonM.A., DockertyM.B.Hepatic function tests: post operative changes with halothane or diethylether anaesthesia. Mayo Clin Proc1966; 41: 599.
5.
AdkikmanS.A., FlanaganT.V., LandmesserC.M.A.Comparative study of serum glutamic pyruvic transaminase changes following anaesthesia with halothane, methoxyflurane and other inhalation agents. Anaesth Analg1966; 45: 819.
6.
InnesR.K.R., StrommeJ.H.Rise in serum creatine phosphokinase associated with agents used in anaesthesia. Br J Anaesth1973; 45: 185.
7.
PhornphutkulK.S., AnurasS., KoffR.S.Causes of increased plasma creatine kinase activity after surgery. Clin Chem1974; 20: 340.
8.
JohnstoneR.R., EgerE.J., StevensW.C.Fluroxene toxicity in dogs: possible mechanisms. Anaesth Analg1974; 53: 998.
9.
BrownB.R., SipesI.G.Biotransformation and hepatotoxicity of halothane. Biochem Pharmacol1977; 26: 2091.
10.
JoceylinP.C.Biochemistry of the SH group. The occurrence, chemical properties, metabolism and biological functions of thiols and disulphides.Academic Press, New York, 1972.
11.
RosenbergP.H.Decrease in reduced glutathione and NADPH and inhibition of glucose-6-phosphate dehydrogenase activity caused by metabolites of flutoxene and halothane. Ann Med Exp Fenn1971; 49: 84.
BrownB.R., SipesI.G., SagalynA.M.Mechanisms of acute hepatic toxicity: chloroform, halothane and glutathione. Anesthesiology1974; 41: 561.
14.
CousinsM.J., SharpJ.H., GourlayG.K., AdamsJ.F.Hepatotoxicity and halothane metabolism in an animal model with application for human toxicity. Anaesth Intens Care1979; 7: 9.
15.
BeutlerE., DuronO., KellyB.H.Improved method for the determination of blood glutathione. J Lab Clin Med1963; 61: 888.
16.
KhutetaK.P., GuptaS.E.Studies on human stress effect of laprotomy on blood ergothioneine and glutathione levels. Ind J Physiol Pharmac1977; 21: 238.
17.
BeutlerE.Disorders in glutathione metabolism. Life Sci1975; 16: 1499.
18.
AgarN.S.Glutathione polymorphism in the sheep red blood cells. Int J Biochem1975; 6: 843.