Repeated sub-apnoeic doses of suxamethonium produce increased neuromuscular block in a hand muscle, measured by integrated electromyogram. The response to the initial dose varies widely between patients. More than 50% of patients showed evidence of non-depolarising block after one dose of suxamethonium. There was a variation between the response of the hand muscle and respiratory muscles.
GibbD.B.Suxamethonium: a review. Part I Physicochemical properties and fate in the body. Anaesth Intens Care1972; 1: 109–118.
2.
Part II Neuromuscular blocking properties. Anaesth Intens Care1973; I: 183–201.
3.
Part III Pharmacological actions of suxamethonium apart from its neuromuscular blocking effect. Anaesth Intens Care1974; II: 9–26.
4.
MillerR.D., WayW.L., HickeyR.F.Inhibition of succinylcholine induced increased intraocular pressure by non-depolarising muscle relaxant. Anesthesiology1968; 29: 123–126.
5.
MillerR.D., WayW.L.Inhibition of succinylcholine-induced increased intragastric pressure by non-depolarising muscle and lidocaine. Anesthesiology1971; 34: 185–188.
6.
FreundF.G., RubinA.P.The need of additional succinylcholine after d-tubocurarine. Anesthesiology1972; 36: 185–187.
7.
BarakaA.Self-taming of succinylcholine induced fasciculations. Anesthesiology1977; 46: 292–293.
8.
CrulJ.F., LongG.L., BrunnerE.A., CoolenJ.M.W.The changing patterns of neuromuscular blockade caused by succinylcholine in man. Anesthesiology1966; 27: 729–735.
9.
LeeC., ChenD., NagelE.L., KatzR.L.Spontaneous recovery of the thumb twitch from neuromuscular block by suxamethonium in anaesthetised man. Br J Anaesth1976; 48: 91–95.
10.
LeeC.Self-antagonism; a possible mechanism of tachyphylaxis in suxamethonium-induced neuromuscular block in man. Br J Anaesth1976; 48: 1097.
11.
LincoffH.A., EllisC.H., DeVoeA.G.The effect of succinylcholine on intraocular pressure. Am J Ophthalmol1955; 40: 501–510.
12.
Khmelevsky YaM., KudrivavtevV.D.Electromyographic characteristic of succinylcholine action after multiple intravenous injections. Eksp. Naya Khirurgiya I. Anesteziologiya (Moscow)1971; 16: 71–76.
13.
CassN.M., LampardD.G., BrownW.A., ColesJ.R.Computer controlled muscle relaxation: a comparison of four muscle relaxants in the sheep. Anaesth Intens Care1976; 4: 16–22.