Paralysis was maintained in the sheep for 30 or 90 minutes by computer-controlled injection of gallamine, pancuronium, alcuronium or d-tubocurarine, using the integrated electromyogram as a measure of neuromuscular transmission. Neostigmine was given and the recovery time measured. In all trials the recovery rise time was no longer than two minutes, but varied between one and two minutes.
References
1.
De AngelisJ.Clinical studies involving neostigmine reversal of d-tubocurarine, gallamine, and pancuronium in man.Anesth Analg Co Res1974; 53: 268.
2.
MillerR.D., LarsonC.P., WayW.L.Comparative antagonism of d-tubocurarine, gallamine, and pancuronium-induced neuromuscular blockades by neostigmine.Anesthesiology1972; 37: 503.
3.
MillerR.D.Antagonism of neuromuscular blockade.Anesthesiology1976; 44: 318.
4.
KatzR.L., WolfeC.E.Neuromuscular and electromyographic studies in man: effects of hyperventilation, carbon dioxide inhalation and d-tubocurarine.Anesthesiology1964; 25: 781.
5.
CannardT.H., ZaimisE.The effect of lowered muscle temperature on the action of neuro-muscular blocking drugs in man.J Physiol1959; 149: 112.
6.
PrestonJ.B., Van MaanenE.F.Effects of frequency of stimulation on paralyzing dose of neuromuscular blocking agents.J Pharmacol Exper Therap1953; 107: 165.
7.
CassN.M., LampardD.G., BrownW.A., ColesJ.R.Computer controlled muscle relaxation: a comparison of four muscle relaxants in the sheep.Anaesth Intens Care1976; 4: 16.
8.
Biglund-RitchieB., WoodsJ.J.Integrated EMG and oxygen uptake during dynamic contractions of human muscles.J App Physiol1974; 36: 475.
9.
LamH.S., MorganD.L., LampardD.G.Derivation of reliable electromyograms and their relation to tension in mammalian skeletal muscles during synchronous stimulation.EEG and Clin Neurophysiol1979; 46: 72.