Two patients who experienced cardiovascular collapse due to anaphylactoid reactions are described.
The first patient showed haemoconcentration which was rapidly restored with colloid solutions and vasoconstrictors. The second patient showed haemoconcentration in spite of massive infusion of crystalloid and repeated adrenaline; her circulatory status was restored with colloid solution.
In acute anaphylactoid reactions both sympathomimetics and colloid solutions are necessary to restore circulation.
References
1.
FisherM. McD. (1975): “Severe histamine mediated reactions to intravenous drugs used in anaesthesia”, Anaesth. Intens. Care, 3, 180.
2.
FisherM. McD. (1978): “Management of anaphylaxis in adverse reactions to intravenous drugs”, ed. WatkinsJ., and Milford WardA.Academic Press. London, page 145.
3.
FisherM. McD. (1977): “Blood volume replacement in acute anaphylactic cardiovascular collapse related to anaesthesia”, Brit. J. Anaesth., 49, 1023.
4.
MurphyP. (1962): “Histamine in anaesthesia”, Brit. J. Anaesth., 34, 397.
5.
PavekK. (1977): “Anaphylactic shock in the monkey; its haemodynamics and mediators”, Acta anaesth. Scand., 21, 293.
