Althesin was used as an induction agent then diluted and administered as a controlled infusion for 60 patients undergoing 66 procedures. Incremental doses of fentanyl were given to provide additional analgesia. There was delayed awakening in 7 patients (12.1%), 3 of whom responded rapidly to narcotic reversal with naloxone. Intracerebral pathology and surgical trauma contributed to the slow recovery in the other 4 patients. Evidence is presented that Althesin infusions reduce the narcotic requirement. Althesin anaesthesia provides good neurosurgical conditions without delay in recovery.
References
1.
ChinL. S., HavillJ. H., and RothwellR. P. G. (1979): “Status Epilepticus Controlled by Althesin Infusion”, Anaesth. Intens. Care, 7, 50.
2.
ClarkeR. S., DundeeJ. W., BarronD. W., and McArdleL. (1968): “Clinical Studies of Induction Agents XXVI, The Relative Potencies of Thiopentone, Methohexitone and Propanidid”, Brit. J. Anaesth., 40, 593.
3.
ClarkeR. S. I., DundeeJ. W., GarrettR. T., McArdleG. K., and SuttonJ. A. (1975): “Adverse reactions to intravenous anaesthetics”, Brit. J. Anaesth., 47, 575.
4.
CrankshawD. P., and Allt-GrahamJ. (1978): “ED50 values for Thiopentone, Methohexital, Propanidid and Alfathesin: A clinical experiment”, Anaesth. Intens. Care, 6, 36.
5.
DuboisM., SavegeT. M., O'CarrollT. M., and FrankM. (1978): “General anaesthesia and the changes on the cerebral function monitor”, Anaesthesia, 33, 157.
6.
DucheneJ. P. (1977): “Alfathesin by continuous infusion supplemented with intermittent pentazocine”, Canad. Anaesth. Soc. J., 24, 702.
7.
DuCailerJ. (1972): “The effects in man of infusions of Alfathesin with particular regard to the cardiovascular system”,Postgrad. Med. J., June supp., 48, 72.
8.
FitchW., BarkerJ., JennettW. B., and McDowallD. G. (1969): “The influence of neuroleptanalgesic drugs on cerebrospinal fluid pressure”, Brit. J. Anaesth., 41, 800.
9.
FitchW., and McDowallD. G. (1969): “Hazards of anaesthesia in patients with intracranial space-occupying lesions; in Cerebral Circulation Vol. 7, No. 3, p 639”.International Anaesthesiology Clinics (ed. McDowallD. G.) Boston: Little Brown.
10.
GardenerA. E., OlsonB. E., and LichtigerM. (1971): “Cerebrospinal fluid pressure during dissociative anaesthesia with ketamine”, Anaesthesiology, 35, 226.
11.
HowellsT. H. (1968): “Intravenous anaesthetics in dental surgery”, Brit. J. Anaesth., 40, 182.
12.
HunterA. R. (1972a): “Thiopentone supplemented anaesthesia for intracranial surgery”, Brit. J. Anaesth., 44, 506.
13.
HunterA. R. (1972b): “Methohexitone as a supplement to nitrous oxide during intracranial surgery”, Brit. J. Anaesth., 44, 1188.
14.
JagoR. H., and RestallJ. (1977): “Total intravenous anaesthesia based on Alphaxalone/alphadolone and pentazocine”, Anaesthesia, 32, 904.
15.
McDowall, D. G., in discussion section in paper by TakahashiT. (1972): “Waveband analysis of EEG patterns during anaesthesia produced by Alfathesin”,Postgrad. Med. J., June supp., 48, 93.
16.
PickerodtV. W. A., McDowallD. G., CoroneosN. J., and KeaneyN. P. (1972): “Effect of Althesin on cerebral perfusion, cerebral metabolism and intracranial pressure in the anaesthetized baboon”, Brit. J. Anaesth., 44, 751.
17.
RamsayM. A. E., SavegeT. M., SimpsonB. R. J., and GoodwinR. (1974): “Controlled sedation with Alphaxalone/Alphadolone”, Brit. Med. J., 22 June, p. 656.
18.
RasmussenN. J., RosendalT., and OvergaardJ. (1978): “Althesin in Neurosurgical Patients: Effects on Cerebral Hemodynamics and Metabolism”, Acta Anaesth. scand., 22, 257.
19.
SaadyA., WongD., and HicksR. G. (1979): Anaesth. Intens. Cure. In press.
20.
SavegeT. M. (1977): “Adverse reactions to Alfathesin”, British Med. J., 2, 735.
21.
SavegeT. M., FoleyE. I., CoultasR. J., WaltonB., StruninL., SimpsonB. R., and ScottD. F. (1971): “CT1341: Some effects in man”, Anaesthesia, 26, 402.
22.
SavegeT. M., RamsayM. A. E., CurranP. J., CotterJ., WallingP. T., and SimpsonB. R. (1975): “Intravenous anaesthesia by infusion”, Anaesthesia, 30, 757.
23.
TurnerJ. M., CoroneosN. J., GibsonR.M., PowellD., NessM. A., and McDowallD. G. (1973): “Effect of Althesin on intracranial pressure in man”, Brit. J. Anaesth., 45, 168.
24.
TakahashiT. (1972): “Waveband analysis of EEG patterns during anaesthesia produced by Althesin”,Postgrad. M. J., June supp., 48, 96.
25.
UppingtonJ. (1973): “Epileptiform convulsions with Althesin”, Anaesthesia, 28, 546.
26.
WollmanH., AlexanderS. C., and CohenP. J. (1967): “Cerebral circulation and metabolism in anaesthetized man”, Clin. Anaesth., 3, 1.
