Five cases of severe anaphylactic reactions to alcuronium are described. Investigation suggested that these are probably true anaphylaxis to the drug. The cases illustrate the value of intradermal testing in detecting the drug involved and the necessity of using colloidal solutions and adrenaline in the management of hypotension due to anaphylaxis.
References
1.
ChanC. S., and YougM. L. (1972): “Anaphylactic reaction to alcuronium”. Brit. J. Anaesth., 44, 103.
2.
DundeeJ. (1976): “Hypersensitivity to intravenous anaesthetic agents”, Brit. J. Anaesth., 48, 57.
3.
EvansP. J. D., and McKinnonI. (1977): “An anaphylactoid reaction to gallamine triethiodide”, Anaesth. In tens. Care, 5, 239.
4.
FisherM. McD. (1975): “Severe histamine mediated reactions to intravenous drugs used in anaesthesia”, Anaesth. Intens. Care, 3, 180.
5.
FisherM. McD. (1976): “Intradermal testing after severe histamine reactions to intravenous drugs used in anaesthesia”, Anaesth. Intens. Care, 4, 97.
6.
FisherM. McD. (1977): “Blood volume replacement in acute anaphylactic cardiovascular collapse related to anaesthesia”, Brit. J. Anaesth., 49, 1023.
7.
FisherM. McD. (1978): “Anaphylactic reactions to gallamine triethiodine”, Anaesth. Intens. Care, 6, 62.
8.
HeathM. (1973): “Bronchospasm in an asthmatic patient following pancuronium”, Anaesthesia’28, 437.
9.
JerumsG., WhittinghamS., and WilsonP. (1967): “Anaphylaxis to suxamethonium”, Brit. J. Anaesth., 39, 73.
10.
LaytonL., LeeS., and DeEldsF. (1961): “Diagnosis of human allergy utilizing passive skin-sensitization in the monkey”, Macaca Irus. Proc. Soc. Exp. Biological. Med., 108, 623.
11.
McQueenE. G. (1977): “Personal communication.
12.
MatthewsM., Ceglarski, and PabariM. (1977): “Anaphylaxis to suxamethonium — a case report”, Anaesth. Intens. Care, 5, 235.
13.
Munro FordR. (1977): “The management of anaphylaxis”, Med. J. Aust., 1, 222.
14.
ParishW. E. (1970): “Short term anaphylactic IgG antibodies in human sera”, Lancet, 2, 591.
15.
RowleyR. W. (1975): “Hypersensitivity reaction to diallylnortoxiferin (Alloferin).” (Abstract)Anaesth. Intens. Care, 3, 74.
16.
StovnerJ., and LundI. (1970): “The muscle relaxants and their antagonists. Brit. J. Anaesth., 42, 235.
17.
WattH. K. (1973): “Anaphylactic shock from gallamine”, N.Z. Soc. Anaesth. Newsletter, 20, 21.