The risk of precipitating a convulsion in epileptic patients with methohexitone has been judged to vary widely. This article reports such complications arising during methohexitone-activated E.E.G. recording in a series of 48 epileptic patients from whom anticonvulsant medication was withheld. Two patients developed grand mat convulsions during induction with methohexitone 1·0%. Two others exhibited status epilepticus of the petit mat type and one of the myoclonic type, after stopping an infusion of 0·09% methohexitone. The specificity for methohexitone-induced convulsions in epileptics or crypto-epileptics is supported by a review of the literature.
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