In infants and piglets subjected to periods of circulatory arrest at 20°C there was close correlation between duration of arrest and delay in return of electroencephalographic activity. Post mortem studies demonstrated histological evidence of brain damage in patients after circulatory arrest at 20°C. Similar histological changes were demonstrated in piglets, including some who had complete E.E.G. and clinical recovery from circulatory arrest.
References
1.
Barratt-BoyesB. G. (1973): “Complete Correction of Cardiovascular Malformations in the First Five Years of Life Using Profound Hypothermia”, in Heart Disease in Infancy: Diagnosis and Surgical Treatment, Editors Barratt-BoyesB. G., NeutzeJ. M. and HarrisE. A.ChurchillLivingstone, Edinburgh and London, pp. 25–36.
2.
BeringE. A. (1974): “Effects of Profound Hypothermia and Circulatory Arrest on Cerebral Oxygen Metabolism and Cerebrospinal Fluid Electrolyte Composition in Dogs”, Journal of Neurosurgery, 39, 199–205.
3.
BrechnerV. L., KavanE. M., BethuneR. W., BauerR. O., and DillonJ. B. (1959): “The Electroencephalographs Effects of Arrested Circulation During Hypothermia”, American Surgeon, 25, 833–842.
4.
CarlsonR. G., LandéA. J., IveyL. A., SubramanianV. A., BlochJ. H., RogozB., LandisB., BaxterJ., PattersonR. H., and LilleheiC. W. (1972): The Landé-Edwards Membrane Oxygenator for Total Cardiopulmonary Support in 110 Patients During Heart Surgery”, Surgery, 72, 913–919.
5.
CarlsonR. G., LandéA. J., LandisB., RogozB.BaxterJ., PattersonR. H., StenzelK., and LillcheiC. W. (1973): “The Landé-Edwards Membrane Oxygenator During Heart Surgery”, J. Thorac. Cardiovasc. Surg., 66, 894–904.
6.
CartmillT. B., OvertonJ. H., and CelermajerJ. M. (1973): “Deep Hypothermia and Perfusion in Infancy”, in Heart Disease in Infancy: Diagnosis and Surgical Treatment, Editors Barratt-BoyesB.C., NeutzeJ. M., and HarrisE. A., Churchill Livingstone, Edinburgh and London, pp. 45–51.
7.
Documenta Geigy (1962): Scientific Tables, 6th Edition, Editor DiemK., Geigy Pharmaceuticals, St. Leonards, N.S.W., pp. 173–178.
8.
EdmundsL. H., and FolkmanJ. (1966): “Cerebral Metabolism During Profound Hypothermia and Circulatory Arrest”, J. Surg. Res., 1, 201–212.
9.
FiskG. C., WrightJ. S., TurnerB. B., BakerW. de C., HicksR. G., LethleanA. K., StaceyR. B., LawrenceJ. C., LawrieG. M., KalninsI., and RoseM. (1974): “Cerebral Effects of Circulatory Arrest at 20 C in the Infant Pig”, Anaesth. Intens. Care, 2, 33–42.
10.
FukukeiI., IyowasaY., KatoS., SakaguchiS., and YoshizawaT. (1960): “Electroencephalogram in Hypothermic Circulatory Arrest”, Japanese Circulation Journal, 30, 821–828.
11.
HamiltonD., ShackletonJ., ReesG. J., and AbbottT. (1973): “Experience with Deep Hypothermia in infancy Using Core Cooling”, in Heart Disease in Infancy: Diagnosis and Surgical Treatment, Editors Barratt-BoyesB. G., NeutzeJ. M., and HarrisE. A., Churchill Livingstone, Edinburgh and London, pp. 52–60.
12.
McMurreyJ. D., BernhardW. F., TarenJ. A., and BeringE. A. (1956): “Studies on Hypothermia in Monkeys; 1. The Effect of Hypothermia on the Prolongation of Permissible Time of Total Occlusion of the Afferent Circulation to the Brain”, Sure;. Gynecol. Obstet., 102, 75–85.
13.
WrightJ. S., LethleanA. K., HicksR. G., TordaT. A., and StaceyR. (1972): “Electroencephalographic Studies During Open Heart Surgery”, J. Thorac. Cardiovasc. Surg., 63, 631–638.
14.
WrightJ. S., FiskG. C., McCullochC. H., TordaT. A., StaceyR., and HicksR. G. (1973): Pediatric Application of the Landé-Edwards Membrane Oxygenator: Continuous Perfusion and Hypothermic Arrest Techniques”, J. Thorac. Cardiovasc. Surg., 65, 503–510.
