A 21-year-old man ingested 120 mg/Kg of technical dieldrin (hexachloro-epoxy-octahydrodimethano-naphthalene), and survived after mannitol catharsis and three days of vigorous anticonvulsive treatment (which included muscle paralysis), β sympathetic blockade and conventional supportive treatment. His progress has been followed for two months with EEG recording and measurements of serum and adipose tissue dieldrin levels. These data suggest that he may have absorbed only a fraction of the ingested dose.
References
1.
BrownV. K., HunterC. G., and RichardsonA. (1964): “A Blood Test Diagnostic of Exposure to Aldrin and Dieldrin”, Brit. J. Industr. Med21, 283–286.
2.
ConleyB. W. (1960): “Occupational Dieldrin Poisoning”, J.A.M.A., 172, 2077–2080.
3.
GarrettsonL. K., and CurleyA. (1969): “Dieldrin: Studies in a Poisoned Child”, Arch. Environ. Health, 19, 814–822.
4.
GowdeyC. W., and StavrakyG. W. (1955): “A Study of the Autonomic Manifestations Seen in Acute Aldrin and Dieldrin Poisoning”, Canad. J. Biochem. and Phiosiol., 33, 272–282.
5.
HayesW. J. (1959): “Report on the Toxicity of Dieldrin to Man”. Supplement and information circular on Toxicity of Pesticides to Man, No. 2, W.H.O.
6.
HayesW. J. (1963): Clinical Handbook on Economic Poisons, Public Health Service Publcn. No. 476, U.S. Government Printing Office, Washington, D.C.
7.
HeathD. F., and VandekarM. (1964): “Toxicity and Metabolism of Dieldrin in Rats”, Brit. J. Industr. Med., 21, 46–51.
8.
HodgeH. C., BoyceA. M., DeichmannW. B., and KraybillH. F. (1967): “Toxicology and No Effect Levels of Aldrin and Dieldrin”, Toxicol. Applied Pharm., 10, 613–675.
9.
HoogendamI., VersteegJ. P. J., and de VliegerM. (1962): “Electroencephalograms in Insecticide Toxicity”, Arch. Environ. Health, 4, 86–94.
10.
HunterC. G., RosenA., WilliamsR. T., ReynoldsJ. G., and WordenA. N. (1960): “Studies in the Fate of Aldrin, Dieldrin and Endrin in the Mammal”, Meded. Landb Hoogesch. Opzoek Stns. Gent., 25, 1296.
11.
HunterC. G., and RobinsonJ. (1967): “Pharmacodynamics of Dieldrin (HEOD) 1, Ingestion by Human Subjects for 18 months”, Arch. Environ Health, 15, 614–626.
12.
HunterC. G., RobinsonJ., and RobertsM. (1969): “Pharmacodynamics of Dieldrin II, Ingestion by Human Subjects for 18–24 Months and Postexposure for 8 Months”, Arch. Environ. Health, 18, 12–21.
13.
KazantzisG., McLaughlinA. T. G., and PriorP. F. (1964): “Poisoning in Industrial Workers by the Insecticide Aldrin”, Brit. J. Industr. Med., 21, 46–51.
14.
KeaneW. T., and ZavonM. R. (1969): “Validity of a Critical Blood Level for Prevention of Dieldrin Intoxication”, Arch. Environ. Health, 19, 36–44.
15.
N.S.W. Department of Public Health (1970): Agricultural Chemicals: A Synopsis of Toxicity and a Guide to Treatment, Booklet ref. G 19601 K5322. Prepared by the Division of Occupational Health.
16.
PeckA. W. (1970): “Impotence in Farm Workers“ Brit. Med. J., 1, 690.