Abstract
The history of steroidal intravenous anaesthesia is traced.
Althesin was used as an induction agent in 60 elective minor gynaecological procedures requiring general anaesthesia, followed by nitrous oxide/oxygen maintenance anaesthesia.
Clinical assessment showed predominantly a transient hypotension (10–20 mm Hg fall in systolic blood pressure), a rise in pulse and respiratory rates. Recovery was smooth, rapid and pleasant.
As an induction agent Althesin (CT 1341) has effects similar to the well-known and established side-effects of the ultra-short-acting barbiturates. The obvious advantage would be for patients in whom barbiturates are contraindicated. The clear-headed, pleasant recovery should enhance its value for outpatient minor procedures requiring general anaesthesia.