Piritramide is a synthetic analgesic of the piperidine group. Reports indicate that it is a potent, long-acting drug and that the incidence of nausea and vomiting following its administration is very low. In this series of 60 cases piritramide 15 mg was compared with morphine 10 mg in a double-blind trial. The drug was found to have a potency similar to that of morphine and a mean duration of action of greater than 6½ hours (morphine 4 ½ hours). The incidence of nausea and vomiting was low with both drugs and piritramide appeared to exert a slight anti-emetic effect.
References
1.
BodmanR. I., MortonH. J. V., and ThomasE. T. (1960): “Vomiting by out-patients after nitrous oxide anaesthesia”, Brit. Med. J., 1, 1327.
2.
DeloozH., and Van De WalleJ. (1968): “Klinische procfneming met Piritramide (R 3365)”, Acta Anaesth. Belg., 19, 23.
3.
DundeeJ. W., ClarkeR. S. J., and LoanW. B. (1965): “A comparison of the sedative and toxic effects of morphine and pethidine”, Lancet, 2, 1262.
4.
DundeeJ. W., and MooreJ. (1960): “Alterations in response to somatic pain associated with anaesthesia. I. An evaluation of a method of analgesiometry”, Brit. J. Anaesth., 32, 396.
5.
EddyN. B., TouchberryC. F., and LiebermanJ. E. (1950): “Synthetic analgesics. I. Methadone isomers and derivatives”, J. Pharmacol. Exp. Therap., 98, 121.
6.
FauvetJ. (1965): “Essais cliniques du R 3365 sur les douleur des cancéreux”, unpublished clinical research report.
7.
FrankG. (1965): “Uber die physical dependence property von Pirinitramid (R 3365)”, Doctor of Medicine thesis (unpublished), University of Marburg (Germany).
8.
FraserH. F. (1963): “1-(3-cyano-3,3-diphenylpropyl)-4-(1-piperidino)-4-piperidine carboxylic acid amide (R 3365, ARC I–D–21)”, Bulletin Drug Addiction and Narcotics, 1963, Addendum 2, 2.
9.
FraserH. F., IsbellH., RosenbergD. E., and WolbackA. B. (1962): “2,2-Diphenyl-4-(1-[4 - (N - piperidino) - 4-carboxamide] - piperidine)-butyronitrile (R–3365, ARC I–D–21)”, Bulletin, Drug Addiction and Narcotics, 1962, 3006.
10.
FraserH. F., Van HornG. D., MartinW. R., WolbackA. B., and IsbellH. (1961): “Methods of evaluating addiction liability. (A) ’ Attitude ’ of opiate addicts towards opiate-like drugs. (B) A short term ’ direct ’ addiction test”, J. Pharmacol. Exp. Therap., 133, 371.
11.
JanssenP. A. J. (1961): “Pirinitramide (R 3365), a potent analgesic with unusual chemical structure”, J. Pharm. Pharmacol., 13, 513.
12.
JørgensenM., DrybergV., and JohansenS. H. (1965): “The effects of piritramide (R 3365) on the respiratory response to CO2 inhalation”, Acta phacmacol. et toxical., 22, 152.
13.
KayB. (1971): “A clinical investigation of piritramide in the treatment of post-operative pain”, Brit. J. Anaesth., 43, 1167.
14.
LundI., EriksonH., MolnarI., and NordahlT. (1965): “Piritramide (R 3365) and morphine. A comparison of their analgesic and respiratory depressant effects”, Nordisk Medecin, 74, 887.
15.
NilssonE. (1963): “Report concerning ’ R 3365’”, unpublished clinical research report.
16.
SaarneA. (1969): “Clinical evaluation of the new analgesic piritramide”, Acta anaesth. Scandinav., 13, 11.
17.
SnyderF. F. (1962): “Opiate action upon labour as an indication of addiction liability”, Bulletin Drug Addiction and Narcotics, 1962, 2814.
18.
SwerdlowM. (1967): “General analgesics used in pain relief: Pharmacology”, Brit. J. Anaesth., 39, 699.
19.
SykesM. K., and VickersM. D. (1970): Principles of Measurement for Anaesthetists, Blackwell Scientific Publications, p. 243.
20.
WeyneF., SchluterJ., and LustP. (1968): “Piritramide, a potent postoperative analgesic with unusually low respiratory depressant, cardiovascular and emetic effects. A preliminary report”, Acta Anaesth. Belg., 19, 33.
