A clinician's perspective on the first 20 years of the Australian and New Zealand Intensive Care Society Clinical Trials Group and its influence on intensive care clinical practice over this same time period. This point of view discusses the importance of the Clinical Trials Group and the significance of several major published research trials.
Australian and New Zealand Intensive Care Society.ANZICS Clinical Trials Group. From http://www.anzics.com.au/ctg. Accessed February 2014.
2.
TengsT.O., AdamsM.E., PliskinJ.S., SafranD.G., SiegelJ.E., WeinsteinM.C.Five-hundred life-saving interventions and their cost-effectiveness. Risk Anal1995; 15: 369–390.
3.
MoranJ.L., BristowP., SolomonP.J., GeorgeC., HartG.K.Mortality and length-of-stay outcomes, 1993–2003, in the binational Australian and New Zealand intensive care adult patient database. Crit Care Med2008; 36: 46–61.
4.
DukeG.J., BarkerA., RasekabaT., HutchinsonA., SantamariaJ.D.A brief review of recent trends in Victorian intensive care, 2000–2011. Crit Care Resusc2014; 16: 24–28.
5.
Mangione-SmithR., ElliottM.N., McDonaldL., McGlynnE.A.An observational study of antibiotic prescribing behavior and the Hawthorne effect. Health Serv Res2002; 37: 1603–1623.
6.
McCarneyR., WarnerJ., IliffeS., van HaselenR., GriffinM., FisherP.The Hawthorne Effect: a randomised, controlled trial. BMC Med Res Methodol2007; 7: 30.
7.
PrasadV., CifuA.The reversal of cardiology practices: interventions that were tried in vain. Cardiovasc Diagn Ther2013; 3: 228–235.
8.
BellomoR., ChapmanM., FinferS., HicklingK., MyburghJ.Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet2000; 356: 2139–2143.
9.
HebertP.C., WellsG., BlajchmanM.A., MarshallJ., MartinC., PagliarelloG.A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med1999; 340: 409–417.
10.
FinferS., BellomoR., BoyceN., FrenchJ., MyburghJ., NortonR.A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med2004; 350: 2247–2256.
11.
MyburghJ.A., FinferS., BellomoR., BillotL., CassA., GattasD.Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med2012; 367: 1901–1911.
12.
SciricaB.M., MorrowD.A.Potassium concentration and repletion in patients with acute myocardial infarction. JAMA2012; 307: 195–196.
13.
CooperD.J., WalleyK.R., WiggsB.R., RussellJ.A.Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study. Ann Intern Med1990; 112: 492–498.
14.
ThieleH., ZeymerU., NeumannF-J, FerencM., OlbrichH-G, HausleiterJ.Intraaortic balloon support for myocar-dial infarction with cardiogenic shock. N Engl J Med2012; 367: 1287–1296.
15.
WoottonD.Bad Medicine: Doctors Doing Harm Since Hippocrates.Oxford University Press, Oxford2006.
16.
GroopmanJ.How Doctors Think.Houghton Mifflin, New York2007.
FinferS., ChittockD.R., SuS.Y., BlairD., FosterD., DhingraV.Intensive versus conventional glucose control in critically ill patients. N Engl J Med2009; 360: 1283–1297.
20.
CooperD.J., RosenfeldJ.V., MurrayL., ArabiY.M., DaviesA.R., D'UrsoP.Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med2011; 364: 1493–1502.
21.
DaviesA.R., MorrisonS.S., BaileyM.J., BellomoR., CooperD.J., DoigG.S.A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness. Crit Care Med2012; 40: 2342–2348.
22.
DoigG.S., SimpsonF., SweetmanE.A., FinferS.R., CooperD.J., HeighesP.T.Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA2013; 309: 2130–2138.
23.
BellomoR., CassA., ColeL., FinferS., GallagherM., LoS.Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med2009; 361: 1627–1638.
24.
KrugerP., BaileyM., BellomoR., CooperD.J., HarwardM., HigginsA.A multicenter randomized trial of atorvasta-tin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med2013; 187: 743–750.
25.
HillmanK., ChenJ., CretikosM., BellomoR., BrownD., DoigG.Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet2005; 365: 2091–2097.
26.
CretikosM.A., ChenJ., HillmanK.M., BellomoR., FinferS.R., FlabourisA.The effectiveness of implementation of the medical emergency team (MET) system and factors associated with use during the MERIT study. Crit Care Resusc2007; 9: 205–212.
27.
TobinA.E., SantamariaJ.D.Medical emergency teams are associated with reduced mortality across a major metropolitan health network after two years service: a retrospective study using government administrative data. Crit Care2012; 16: R210.
28.
Cochrane Injuries Group.Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ1998; 317: 235–240.
29.
AntonelliM., SandroniC.Hydroxyethyl starch for intravenous volume replacement: more harm than benefit. JAMA2013; 309: 723–724.
30.
BellomoR., WarrillowS.J., ReadeM.C.Why we should be wary of single-center trials. Crit Care Med2009; 37: 3114–3119.
31.
CantarovichF., RangoonwalaB., LorenzH., VerhoM., EsnaultV.L.M.High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicent-er trial. Am J Kidney Dis2004; 44: 402–409.
32.
PeterJ.V., JohnP., GrahamP.L., MoranJ.L., GeorgeI.A., BerstenA.Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ2008; 336: 1006–1009.
33.
ZehenderM., KasperW., JustH.Lidocaine in the early phase of acute myocardial infarction: the controversy over prophylactic or selective use. Clin Cardiol1990; 13: 534–539.
34.
MaitlandK., KiguliS., OpokaR.O., EngoruC., Olupot-OlupotP., AkechS.O.Mortality after fluid bolus in African children with severe infection. N Engl J Med2011; 364: 2483–2495.
35.
BickellW.H., WallM.J.Jr., PepeP.E., MartinR.R., GingerV.F., AllenM.K., MattoxK.L.Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med1994; 331: 1105–1109.
36.
SandhamJ.D., HullR.D., BrantR.F., KnoxL., PineoG.F., DoigC.J.A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med2003; 348: 5–14.
