We audited patients with anaphylaxis to muscle relaxants during anaesthesia referred to the Department of Anaesthesia at the Royal Adelaide Hospital between the start of 2000 and the end of 2009. Of the 220 patients tested during this period, 43 had a positive intradermal test to the muscle relaxant given during their anaesthetic. The majority of these were to rocuronium and suxamethonium. Where rocuronium was the index agent, 65% of patients cross-reacted with another relaxant and 29% of patients with suxamethonium as their index agent demonstrated cross-reaction with another relaxant.
FisherM.M., BaldoB.A.The incidence and clinical features of anaphylactic reactions during anesthesia in Australia. Ann Fr Anesth Reanim1993; 12: 97–104.
MertesP.M., LaxenaireM.C.Anaphylactic and anaphylactoid reactions occurring during anaesthesia in France. Seventh epidemiologic survey (January 2001-December 2002). Ann Fr Anesth Reanim2004; 23: 1133–1143.
5.
MertesP.M., LaxenaireM.C., AllaF.Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000. Anesthesiology2003; 99: 536–545.
6.
LaxenaireM.C., MertesP.M.Anaphylaxis during anaesthesia. Results of a two-year survey in France. Br J Anaesth2001; 87: 549–558.
7.
LaxenaireM.C.Epidemiology of anesthetic anaphylactoid reactions. Fourth multicenter survey (July 1994-December 1996). Ann Fr Anesth Reanim1999; 18: 796–809.
8.
SiemiatkowskiA., KosciuczukU.The role of tryptase assay in recognition of anaphylactic reaction to muscle relaxants. Anestezjol Intens Ter2010; 42: 31–36.
9.
ThienthongS., HintongT., PulnitipornA.The Thai Anesthesia Incidents Study (THAI Study) of perioperative allergic reactions. J Med Assoc Thai2005; 88Suppl 7: S128–S133.
10.
MertesP.M., TajimaK., Regnier-KimmounM.A., LambertM., IohomG., Gueant-RodriguezR.M.Perioperative anaphylaxis. Med Clin North Am2010; 94: 761–789, xi.
11.
HeierT., GuttormsenA.B.Anaphylactic reactions during induction of anaesthesia using rocuronium for muscle relaxation: a report including 3 cases. Acta Anaesthesiol Scand2000; 44: 775–781.
12.
MitsuhataH., MatsumotoS., HasegawaJ.The epidemiology and clinical features of anaphylactic and anaphylactoid reactions in the perioperative period in Japan. Masui1992; 41: 1664–1669.
13.
VervloetD.Allergy to muscle relaxants and related compounds. Clin Allergy1985; 15: 501–508.
14.
LaxenaireM.C., Moneret-VautrinD.A., VervloetD.The French experience of anaphylactoid reactions. Int Anesthesiol Clin1985; 23: 145–160.
15.
StellatoC., MaroneG.Mast cells and basophils in adverse reactions to drugs used during general anesthesia. Chem Immunol1995; 62: 108–131.
16.
SageD.Intradermal drug testing following anaphylactoid reactions during anaesthesia. Anaesth Intensive Care1981; 9: 381–386.
17.
HarboeT., GuttormsenA.B., IrgensA., DybendalT., FlorvaagE.Anaphylaxis during anesthesia in Norway: a 6-year singlecenter follow-up study. Anesthesiology2005; 102: 897–903.
18.
GalletlyD.C., TreurenB.C.Anaphylactoid reactions during anaesthesia. Seven years’ experience of intradermal testing. Anaesthesia1985; 40: 329–333.
19.
LoberaT., AudicanaM.T., PozoM.D., BlascoA., FernandezE., CanadaP.Study of hypersensitivity reactions and anaphylaxis during anesthesia in Spain. J Investig Allergol Clin Immunol2008; 18: 350–356.
20.
BhanankerS.M., O'DonnellJ.T., SalemiJ.R., BishopM.J.The risk of anaphylactic reactions to rocuronium in the United States is comparable to that of vecuronium: an analysis of food and drug administration reporting of adverse events. Anesth Analg2005; 101: 819–822, table of contents.