We present the case of a 28-year-old female with a previous diagnosis of C1 esterase inhibitor deficiency presenting for dental extractions under general anaesthesia. Following prophylaxis with a new bradykinin receptor 2 antagonist (icatibant), surgery was carried out uneventfully with an unremarkable postoperative course.
LevyJ.H., FreibergerD.J., RobackJ.Hereditary angioedema: current and emerging treatment options. Anesth Analg2010; 110: 1271–1280.
2.
KarlisV., GlickmanR.S., SternR., KinneyL.Hereditary angioedema; case report and review of management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1997; 83: 462–464.
3.
CugnoM., NussbergerJ., CicardiM., AgostoniA.Bradykinin and the pathophysiology of angioedema. Int Immunopharmacol2003; 3: 311–317.
4.
CicardiM., BanerjiA., BrachoF., MalbranA., RosenkranzB., RiedlM.Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema. N Engl J Med2010; 363: 532–541.
5.
BowenT., CicardiM., FarkasM., BorkK., LonghurstH.J., ZurawB.2010International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol2010; 6: 1–13.
6.
MooreG.P., HurleyW.T., PaceS.A.Hereditary angioedema. Ann Emerg Med1988; 17: 1082–1086.
7.
ZurawB.L.Hereditary angioedema. N Engl J Med2008; 359: 1027–1036.
8.
NagyN., GrattanC.E., McGrathJ.A.New Insights into hereditary angio-edema: Molecular diagnosis and therapy. Australas J Dermatol2010; 51: 157–162.
9.
CichoS., MartinL., HenniesH.C., MullerF., Van DriesscheK., KarpushovaA.Increased activity of coagulation factor 12 (Hageman Factor) causes hereditary angioedema type 3. Am J Hum Genet2006; 79: 1098–1104.
10.
ChinniahN., KatelarisC.H.Hereditary angioedema and pregnancy. Aust N Z J Obstet Gynaecol2009; 49: 2–5.
WallR.T., FrankM., HahnM.A review of 25 patients with hereditary angioedema requiring surgery. Anesthesiology1989; 71: 309–311.
13.
LumryW.R., LiH.H., LevyR.J., PotterP.C., FarkasH., MoldovanD.Randomised placebo-controlled trial of the bradykinin B2 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema. Ann Allergy Asthma Immunol2011; 107: 529–539.
14.
BouilletL., Boccon-GibodI., PonardD., DrouetC., CesbronJ.Y., Dumestre-PerardC.Bradykinin receptor 2 antagonist (icatibant) for hereditary angioedema type III attacks. Ann Allergy Asthma Immunol2009; 103: 448.
15.
ClemensP.C.Short-term prophylactic treatment of hereditary angioedema (HAE) type 2 with icatibant. Poster presentation at the 30th Congress of the European Academy of Allergy and Clinical Immunology, 11-15 June 2011, Istanbul, Turkey.
16.
MarquesL.Short term prophylactic treatment of hereditary angioedema with icatibant. Allergy2010; 65: 137–138.