The Microcirculation,Regional Blood Flow and Tissue Oxygenation: Will New Technologies Drive New Resuscitation Goals?

De Backer D. , Dubois M.J. Assessment of the microcirculatory flow in patients in the intensive care unit. Curr Opin Crit Care 2001; 7: 200–203.

Bateman R.M. , Sharpe M.D. , Ellis C.G. Bench-to-bedside review: microvascular dysfunction in sepsis – hemodynamics, oxygen transport, and nitric oxide. Crit Care 2003; 7: 359–373.

Buchele G.L. , Ospina-Tascon G.A. , De Backer D. How microcirculation data have changed my clinical practice. Curr Opin Crit Care 2007; 13: 324–331.

Spronk P.E. , Zandstra D.F. , Ince C. Bench-to-bedside review: sepsis is a disease of the microcirculation. Crit Care 2004; 8: 462–468.

Nanas S. , Gerovasili V. , Renieris P. , Angelopoulos E. , Poriazi M. , Kritikos K. Non-invasive assessment of the microcirculation in critically ill patients. Anaesth Intensive Care 2009; 37: 733–739.

Jung C. , Lauten A. , Roediger C. , Fritzenwanger M. , Schumrn J. , Figulla H.R. In vivo evaluation of tissue microflow under combined therapy with extracorporeal life support and intraaortic balloon pump. Anaesth Intensive Care 2009; 37: 833–835.

Ward K.R. , Ivatury R.R. , Barbee R.W. , Terner J. , Pittman R. , Filho I.P. Near infrared spectroscopy for evaluation of the trauma patient: a technology review. Resuscitation 2006; 68: 27–44.

Ince C. The microcirculation is the motor of sepsis. Crit Care 2005; 9(Suppl 4): S13–19.

Goedhart P.T. , Khalilzada M. , Bezemer R. , Merza J. , Ince C. Sidestream dark field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express 2007; 15: 15101–15114.

Fries M. , Weil M.H. , Sun S. , Huang L. , Fang X. , Cammarata G. Increases in tissue PCO₂ during circulatory shock reflect selective decreases in capillary blood flow. Crit Care Med 2006; 34: 446–452.

Mathura K.R. , Vollebregt K.C. , Boer K. , De Graaff J.C. , Ubbink D.T. , Ince C. Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol 2001; 91: 74–78.

Groner W. , Winkelman J.W. , Harris A.G. , Ince C. , Bourna G.J. , Messmer K. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999; 5: 1209–1212.

De Backer D. , Creteur J. , Preiser J-C , Dubois M-J , Vincent J-L Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002; 166: 98–104.

Spronk P.E. , Ince C. , Gardien M.J. , Mathura K.R. , Oudemans-van Straaten H.M. , Zandstra D.F. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002; 360: 1395–1396.

Trzeciak S. , Dellinger R.P. , Parrillo J.E. , Guglielmi M. , Bajaj J. , Abate N.L. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007; 49: 88–98, 98.e1–2.

Sakr Y. , Dubois M-J , De Backer D. , Creteur J. , Vincent J-L , Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004; 32: 1825–1831.

Trzeciak S. , McCoy J.V. , Phillip D.R. , Arnold R.C. , Rizzuto M. , Abate N.L. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008; 34: 2210–2217.

Levy M.M. , Macias W.L. , Vincent J-L , Russell J.A. , Silva E. , Trzaskoma B. Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 2005; 33: 2194–2201.

De Backer D. , Creteur J. , Dubois M-J , Sakr Y. , Vincent J-L Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 2004; 147: 91–99.

Rivers E. , Nguyen B. , Havstad S. , Ressler J. , Muzzin A. , Knoblich B. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368–1377.