Effect of Pre-emptive Alveolar Recruitment Strategy before Pneumoperitoneum on Arterial Oxygenation during Laparoscopic Hysterectomy

Abstract

In a randomised, controlled, single-blind trial, we examined the effect of a pre-emptive alveolar recruitment strategy on arterial oxygenation during subsequent pneumoperitoneum. After intubation, 50 patients were randomly allocated to receive either tidal volume 10 ml/kg with no positive end-expiratory pressure (group C) or alveolar recruitment strategy of 10 manual breaths with peak inspiratory pressure of 40 cmH₂O plus positive end-expiratory pressure of 15 cmH₂O before gas insufflation (group P). During pneumoperitoneum, group P was ventilated with the same setting as group C (FiO₂=0.35, tidal volume 10 ml/kg). P_aO₂ measured during peumoperitoneum was higher in group P than in group C (166∓32 mmHg vs 145∓34 mmHg at 15 minutes, P=0.028, 155∓30 mmHg vs 136∓32 mmHg at 30 minutes, P=0.035). Alveolar-arterial oxygen gradient in group P increased less after gas insufflation (13∓9 to 60∓34 mmHg vs 10∓9 to 37∓31 mmHg, P=0.013). We conclude that the alveolar recruitment strategy we applied before insufflation of the peritoneal cavity may improve oxygenation during laparoscopic hysterectomy.