Water shortage has plagued the social development and human well-being of global closed basins. However, the hydroclimate research on different time scales in these regions remains inadequate at a global scale. In this paper, the hydrological responses from global closed basins to millennial-scale and centennial-scale cold/warm events since the Last Glacial Maximum were explored. Closed-basin lake records indicate that the westerlies-dominated closed basins are generally wetter during cold events than the corresponding warm ones on the millennial and centennial scales. In contrast, the monsoon-influenced closed basins prevail wetter climates during warm events. According to the hydroclimate simulations, precipitation seasonality plays a significant role in causing above spatial–temporal patterns. There is more winter rainfall in westerlies-dominated closed basins during cold events in the Last Glacial Maximum and Little Ice Age and more summer rainfall in monsoon-influenced closed basins during warm events in the mid-Holocene and Medieval Climate Anomaly. Under modern and future global warming, the hydroclimate changes in global closed basins show more regional differentiation, resulting in wetter mid-latitude Asian and low-latitude African closed basins but drier southwest North American and Australian closed basins.
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