In this article, the author attempts to demonstrate a relationship between neurobiological dysfunctions and/or genetically determined deviant behavior and personality traits as well as moral abnormalities. Data from neuroscience show that a number of neurological dysfunctions are linked to cognitive and emotional disturbances. Cognitive and emotional abnormalities, in turn, are frequently related to moral dysfunctions. Moreover, neurological disorders can produce dramatic psychological and social problems, personality changes, and behavioral problems in patients. Those mental, emotional, and psychosocial problems and related moral dysfunctions are frequently linked to violence and/or criminal behavior. Genetic research found evidence of inheritability of antisocial traits, which interfere with moral development and activities. This information has consequences for any assessment and disposition within the legal system. More research on the interrelationship between neuro(bio)logical, genetic, emotional, and mental aspects of moral dysfunctions is needed for the development of adequate treatment, prevention, and intervention programs.
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References
1.
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. R. (1995). Fear and the human amygdala. The Journal of Neuroscience, 15, 5879-5891.
2.
Alm, P. O., af-Klinteberg, B., Humble, K., Leppert. J., Sorensen, S., Thorell, L. H., Lidberg, L., & Oreland, L. (1996). Criminality and psychopathy as related to thyroid activity in former juvenile delinquents. Acta Psychiatrica Scandinavica, 94, 112-117.
3.
American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (DSM-IV) (4th ed.). Washington, DC: Author.
4.
Benjamin, J., Ebstein, R. P., & Belmaker, R. H. (1997). Personality genetics. Israelian Journal of Psychiatry and Related Sciences, 34, 270-280.
5.
Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996). Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genetics, 12, 81-84.
6.
Ben-Ze’ev, A. (1997). Emotions and morality. Journal of Value Inquiry, 31, 195-212.
7.
Bond, E. J. (1990). Could there be a rational grounded morality? Journal of Philosophical Research, 15, 15-45.
8.
Cahill, L., Rabinsky, R., Markowitsch, H. J., & McGaugh, J. L. (1995). The amygdala and emotional memory. Nature, 37, 295-296.
9.
Clark, G. A. (1995). Emotional learning. Fear and loathing in the amygdala. CurrentBiology, 5, 246-248.
10.
Coccaro, E. F., Bergeman, C. S., Kavoussi, R. J., & Seroczynski, A. D. (1997). Inheritability ofaggres sion and irritability: A twin study ofthe Buss-Durkee aggression scales in adult male subjects. Biological Psychiatry, 41, 273-284.
11.
Coccaro, E. F., Bergeman, C. S., & McClearn, G. E. (1993). Inheritability ofirritable impulsiveness: A study oftwins reared together and apart. Psychiatry Research, 48, 229-242.
12.
Constantino, J. N., Morris, J. A., & Murphy, D. L. (1997). CSF 5-HIAA and family history of antisocial personality disorder in newborns. American Journal of Psychiatry, 154, 1771-1773.
13.
Costin, F., & Draguns, J. (1989). Abnormal psychology: Patterns, issues, interventions (pp. 354-356). New York: John Wiley.
14.
Damasio, A. R. (Ed.). (1994). Descartes error. New York: G. P. Putman.
15.
Darwin C. (Ed.). (1872). The expression of the emotions in animals. Chicago: University ofChicago Press.
16.
Davidson, R. J., & Sutton, S. K. (1995). Affective neuroscience: The emergence of a discipline. CurrentOpinions in Neurobiology, 5, 217-224.
17.
DeLancey, C. (1997). Emotion and the computational theory ofmind. Two sciences of mind: Readings in cognitive science and consciousness. Advances in consciousness research (Vol. 9, pp. 234-256). Philadelphia: John Benjamin.
18.
Devinski, O., Morell, M. J., & Vogt, B. A. (1995). Contributions ofanterior cingulate cortex to behav ior. Brain, 118, 279-306.
19.
Dietrich, D. E., Schedlowski, H., Bode, L., Ludwig, H., & Emrich, H. M. (1998). A viropsychoimmunological disease-model ofa subtype affective disorder. Pharmacopsychiatry, 31, 77-82.
20.
Dolan, M. (1994). Psychopathy: A neurobiological perspective. British Journal of Psychiatry, 165, 151-159.
21.
Drevets, W. C., & Raichle, M. E. (1998). Reciprocal suppression ofregional cerebral blood flow dur ing emotional versus higher cognitive processes: Implications for interactions between emotion and cognition. Cognition and Emotion, 12, 353-385.
22.
Ebstein, R. P., & Belmaker, R. H. (1997). Saga ofan adventure gene: Novelty seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism. Molecular Psychiatry, 2, 381-384.
23.
Ebstein, R. P., Nemanov, L., Klotz, I., Gritsenko, I., & Belmaker, R. H. (1997). Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait ofNovelty Seeking. Molecular Psychiatry, 2, 472-477.
24.
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait ofNovelty Seeking. Nature Genetics, 12, 78-80.
25.
Eslinger, P. J. (1998). Neurological and neuropsychological bases ofempathy. European Neurology, 39, 193-199.
26.
Gorenstein, E. E. (1982). Frontal lobe functions in psychopaths. Journal of Abnormal Psychology, 91, 369-370.
27.
Gottesman, I. I., & Goldsmith, H. H. (1994). Developmental psychopathology ofantisocial behavior: Inserting genes into its ontogenesis and epigenesis. In C. A. Nelson (Ed.), Threats to optimal development, integrating biological, psychological, and social risk factors (pp. 69-104). Hillsdale, NJ: Lawrence Erlbaum.
28.
Hales, R. E., Yudofsky, S. C. (1997). Textbook of neuropsychiatry. New York: American Psychiatric Press.
29.
Izard, C. E., & Ackerman, B. P. (1998). Emotions and self-concept across the life span. In K. Warner Schaie, & M. Powell Lawton (Eds.), Annual review of gerontology and geriatrics: Vol. 17. Focus on emotion and adult development. Annual review of gerontology and geriatrics (pp. 1-26). New York: Springer.
30.
Kant, I. (Ed.). (1870). Grundlegung zur Metaphysik der Sitten. Berlin: Heimann.
31.
Kolancyk A. (1997). O wspolzmiennosci emocji i poznania [On covariability ofemotion and cognition] Przeglad Psychologiczny, 40, 57-79.
32.
Krueger, R. F., Schmutte, P. S., Caspi, A., Moffitt, T. E., Campbell, K., & Silva, P. A. (1994). Personality traits are linked to crime among men and women: Evidence from a birth cohort. Journal of Abnormal Psychology, 103, 328-338.
33.
Kutas, M., & Federmeier, K. D. (1998). Minding the body. Psychophysiology, 35, 135-150.
34.
Levin, H. S., Goldstein, F. C., & Williams, D. H. (1989). The contribution offrontal lobe lesions in the neuro-behavioral outcome ofclosed head injury. In H. S. Levin, H. M. Eisenberg, & L. Benton (Eds.), Frontal lobe function and dysfunction. Thousand Oaks, CA: Sage.
35.
Lewis, M., & Michelson, L. (Eds.) (1980). Children’s emotions and moods. Developmental theory and measurement. New York: Plenum.
36.
Linnoila, M., Virkkunen, M., George, M. L., Eckhard, M., Higley, J. D., Nielsen, D., & Goldman, D. (1994). Serotonin, violent behavior and alcohol. Exs, 71, 155-163.
37.
Lykken, D. (1995). The antisocial personalities. Hillsdale, NJ: Lawrence Erlbaum.
38.
Magnusson, D. (1996). The patterning ofantisocial behavior and autonomic reactivity. In D. M. Stoff, R. D. Cairns (Eds.), Aggression and violence: Neurobiological, biosocial and genetic perspectives(pp. 291-308). Hillsdale, NJ: Lawrence Erlbaum.
39.
Martens, W.H.J. (1997). Psychopathy and maturation (Master’s thesis, Tilburg University). Maastricht, the Netherlands: Shaker.
40.
Martens, W.H.J. (1999) Marcel–A case report ofa violent sexual psychopath in remission. International Journal of Offender Therapy and Comparative Criminology, 43, 391-399.
41.
Martens, W.H.J. (in press-a) A case report ofan extremely violent rapist with borderline personality disorder in remission. Archives of Sexual Behavior.
42.
Martens, W.H.J. (in press-b). Ethical and moral capacities ofthe psychopath. In D. C. Thomasma, D. N. Weisstub, & T. Kimbrough Kushner (Eds.), International library of ethics, law and the new medicine. Dordrecht: Kluwer Academic Publishers.
43.
Martens, W.H.J. (2000). Antisocial and psychopathic personality disorders: causes, course and remission: A review article. International Journal of Offender Therapy and Comparative Criminology, 44, 406-430.
44.
McBurnett, K., Pfiffner, L. J., Capasso, L., Lahey, B. B., & Loeber, R. (1997). Children’s aggression and DSM-III-R symptoms predicted by parent psychopathology, parenting practices, cortisol, and SES. In A. Raine, P. A. Brennan, D. P. Farrington, & S.A. Mednick (Eds.), Biosocial bases of violence (NATO ASI Series, Series A: Life sciences, Vol. 292, pp. 345-348). New York: Plenum.
45.
McGuigan, F. J. (1997). A neuromuscular model ofmind with clinical and educational applications. Journal of Mind and Behavior, 8, 351-370.
46.
Nielsen, D. A., Goldman D., Virkkunen, M., Tokola, R., Rawlings, R., & Linnoila, M. (1994). Suicidability and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Archives of General Psychiatry, 51, 34-38.
47.
Noble, E. P., Ozkaragoz, T. Z., Ritchie, T. L., Zhang, X., Belin, T. R., & Sparkes, R. S. (1998). D2 and D4 dopamine receptor polymorphisms and personality. American Journal of Medical Genetics, 81, 257-267.
48.
Oakley, J. (1991). Morality and the emotions. Boston: Routlege Kegan Paul.
49.
Pally, R. (1998). Emotional processing: The mind-body connection. International Journal of Psychoanalysis, 9, 349-462.
50.
Pinker, S. (1997). How the mind works. New York: Norton.
51.
Raine, A. (1996). Autonomic nervous system factors underlying disinhibited, antisocial and violent behavior. Biosocial perspective and treatment implications. Annals of the New York Academy of Sciences, 794, 46-59.
52.
Raine, A., Lencz, T., Bihrle, S., LaCasse, L., & Colletti, P. (2000). Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry, 57, 119-127.
53.
Raine, A., Venables, P. H., & Mednick, S. A. (1997). Low resting heart rate at age 3 years predisposes to aggression at age 11 years: Evidence from the Mauritius Child Health Project. Journal of the American Academy of Child AdolescentPsychiatry, 36, 1457-1464.
54.
Raine, A., Venables, P. H., & Williams, M. (1996). Better autonomic conditioning and faster electrodermal half-recovery time at age 15 years as possible protective factors against crime at age 29 years. Developmental Psychology, 32, 624-630.
55.
Robinson, R. G., & Starkstein, S. E. (1997). Neuropsychiatric aspects ofcerebrovascular disorders. In S. C. Yudofsky & R. E. Hales (Eds.), The American psychiatric press textbook of neuropsychiatry(pp. 607-634). Washington, DC: American Psychiatric Press.
56.
Sander, T., Harms, H., Dufeu, P., Kuhn, S., Hoehe, M., Lesch, K., Rommelspacher, H., & Schmidt, L. G. (1998). Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biological Psychiatry, 43, 908-912.
57.
Schoenbaum, G., Chiba, A. A., & Gallagher, M. (1998). Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning. Nature Neuroscience, 1, 155-159.
58.
Schoenbaum, G., Chiba, A. A., & Gallagher, M. (1999). Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. Journal of Neuroscience, 19, 1876-1884.
59.
Silver, J. M., Hales, R. E., & Yudofsky, S. C. (1997). Neuropsychiatric aspects of traumatic brain injury. In S. C. Yudofsky & R. E. Hales (Eds.), The American psychiatric press textbook of neuropsychiatry (pp. 521-560). Washington, DC: American Psychiatric Press.
60.
Stålenheim, E. G., Eriksson, E., von Knorring, L., & Wide, L. (1998). Testosterone as a biological marker in psychopathy and alcoholism. Psychiatry Research, 77, 79-88.
61.
Stålenheim, E. G., von Knorring, L., & Wide, L. (1998). Serum levels ofthyroid hormones as biologi cal markers in a Swedish forensic psychiatric population. Biological Psychiatry, 43, 755-761.
62.
Susman, E. J., & Ponirakis, A. (1997). Hormones—context interaction and antisocial behavior in youth. In A. Raine, P. A. Brennan, D. P. Farrington, & S. A. Mednick (Eds.), Biosocial bases of violence (NATO ASI series: Series A: Life sciences, Vol. 292, pp. 251-269). New York: Plenum.
63.
Tremblay, L., & Schultz, W. (1999). Relative reward preference in primate orbitofrontal cortex. Nature, 398, 704-708.
64.
Tsujimoto, T., Ogawa, M., Tsukada, M., Kakiuchi, T., & Sasaki, K. (1998). Activation ofthe ventral and mesial frontal cortex of the monkey by self-initiated movement tasks as revealed by positron emission tomography. Neuroscience Letters, 258, 117-120.
65.
Van Goozen, S.H.M., Matthys, W., Cohen-Kettenis, P. T., Thijsen, J. H., & van England, H. (1998). Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. Biological Psychiatry, 43, 531-539.
66.
Virkkunen, M. (1985). Urinary free cortisol secretion in habitually violent offenders. Acta Psychiatrica Scandinavica, 72, 40-44.
67.
Virkkunen, M., Goldman, D., & Linnoila, M. (1996). Serotonin in alcoholic violent offenders. Ciba Foundation Symposium, 194, 168-177, 177-182.
68.
Virkkunen, M., Kallio, E., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., & Karonen, S. L. (1994). Personality profiles and state aggressiveness in Finnish violent offenders, impulsive fire setters, and healthy volunteers. Archives of General Psychiatry, 51, 28-33.
69.
Virkkunen, M., Rawlings, R., & Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., & Karonen, S. L., & Linnoila, M. (1994). CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry, 51, 20-27.
70.
World Health Organization. (1992). ICD-10: The international statistical classification of diseases and related health problems. Geneva: Author.
71.
Yudofsky, S. C., & Hales, R. E. (Eds.). (1997). The American Psychiatric Press textbook of neuropsychiatry. Washington, DC: American Psychiatric Press.
72.
Zuckerman, M. (1994). Behavioral expressions and biosocial bases of sensation seeking. New York: Cambridge University Press.
