Forty-five cases of renal dysplasia in dogs are examined. Microscopic lesions of dysplasia include asynchronous differentiation of nephrons, persistent mesenchyme, persistent metanephric ducts, atypical tubular epithelium, and dysontogenic metaplasia. These may be distinguished from secondary lesions including compensatory hypertrophy and hyperplasia of the nephron and a variety of degenerative and inflammatory lesions. Although morphological features of renal dysplasia in dogs differ somewhat from those in man, microscopic criteria used in the diagnosis of human dysplasia may be useful when applied to the dog.
References
1.
BernsteinJ:
Congenital malformations of the kidney.In:
Strauss and Welt's Diseases of the Kidney,
ed. EarleyGottschalk,
3rd ed.,
pp. 1089–1107.
Little, Brown, and Co,
Boston,
1979
2.
BlythHOckendenBG:
Polycystic disease of kidneys and liver presenting in childhood.J Med Genet8:
257–284,
1971
3.
CainDRGriggsDLackeyDAKaganBM:
Familial renal agenesis and total dysplasia.Am J Dis Child128:
337,
1974
4.
ColeBRKaufmanRLMcAlisterWHKissaneJM:
Bilateral renal dysplasia in three siblings. Report of a survivor.Clin Nephrol5:
83–87,
1976
5.
CottrellMBFranklinJR:
Congenital nephrosclerosis in a Lhasa apso.Vet Med/Small Anim Clin78:
1221–1223,
1983
6.
DiBartolaSPChewDJBoyceJT:
Juvenile renal disease in related standard poodles.J Am Vet Med Assoc183:
693–696,
1983
7.
EriccsonNOIvemarkBI:
Renal dysplasia and pyelonephritis in infants and children. Part II. Primitive ductules and abnormal glomeruli.Arch Pathol66:
264–269,
1958
8.
EriksenKGrondalenJ:
Familial renal disease in soft-coated wheaten terriers.J Sm Anim Pract25:
489–500,
1984
9.
FarkasMCFarkasJNElasserD:
Congenital polycystic kidneys in a dog.Anim Hosp3:
289–209,
1967
10.
FoxMW:
Inherited polycystic mononephrosis in the dog.J Hered55:
29–30,
1964
11.
GranthamJJ:
Polycystic kidney disease: a predominance of giant nephrons.Am J Physiol244:
F3–F10,
1983
12.
GranthamJJ:
Polycystic renal disease.In:
Strauss and Welt's Diseases of the Kidney,
ed. EarlyGottschalk,
3rd ed.,
pp. 1123–1146.
Little, Brown, and Co,
Boston,
1979
13.
HaweRSLoebWF:
Caudal vaginal agenesis and progressive renal disease in a Shih Tzu.J Am Anim Hosp Assoc20:
123–130,
1984
14.
JubbKVHKennedyPCPalmarN:
The urinary system: anomalies of development.In:
Pathology of Domestic Animals,
3rd ed.,
vol. 2,
pp. 350–356.
Academic Press,
New York,
1985
15.
Kan warYSCaroneFA:
Reversible changes of tubular cell and basement membrane in drug-induced renal cystic disease.Kidney Intl26:
35–43,
1984
16.
KellyDF:
Pyelonephritis and renal response to infection.In:
Canine Nephrology,
ed. BoveeKC,
p. 481.
Harwal Publ. Co,
Philadelphia,
1984
17.
KissaneJM:
Development of the kidney.In:
Pathology of the Kidney,
ed. Heptinstall,
2nd ed.,
pp. 51–68.
Little, Brown, and Co,
Boston,
1974
18.
KissaneJM:
Congenital malformations.In:
Pathology of the Kidney,
ed. Heptinstall,
2nd ed.,
pp. 69–120.
Little, Brown, and Co,
Boston,
1974
19.
KlopferUNeumannFTraininR:
Renal cortical hypoplasia in a Keeshond litter.Vet Med/Small Anim Clin70:
1081–1083,
1975
20.
KlopferUNobelTAKaminskiR:
A nephropathy similar to renal cortical hypoplasia in a Yorkshire Terrier.Vet Med/Small Anim Clin73:
327–329,
1978
21.
LangmanJ:
Medical Embryology; Human Development—Normal and Abnormal,
pp. 116–127.
Williams & Wilkins Co,
Baltimore,
1963
22.
LuckeVMKellyDFDarkePGGGaskellCJ:
Chronic renal failure in young dogs—possible renal dysplasia.J Small Anim Pract21:
169–181,
1980
23.
McKennaSCCarpenterJL:
Polycystic disease of the kidney and liver in the Cairn terrier.Vet Pathol17:
436–442,
1980
24.
McQueenSDDirectoACLloricoBF:
Bilateral congenital polycystic kidneys with vague symptomatology in a dog (a case report).Vet Med/Small Anim Clin70:
1167–1171,
1975
25.
MurtiGS:
Agenesis and dysgenesis of the canine kidneys.J Am Vet Med Assoc146:
1120–1123,
1965
26.
NashASKellyDFGaskellCJ:
Progressive renal disease in soft-coated wheaten terriers: possible familial nephropathy.J Small Anim Pract25:
479–487,
1984
27.
NodenDMdeLahuntaA:
The Embryology of Domestic Animals. Developmental Mechanisms and Malformations,
pp. 312–327.
Williams & Wilkins Co,
Baltimore,
1985
28.
NorrdinRW:
Fibrous osteodystrophy with facial hyperostosis in a dog with renal cortical hypoplasia.Cornell Vet65:
173–186,
1975
29.
O'BrienTDOsborneCAYanoBLBainesDM:
Clinicopathologic manifestations of progressive renal disease in Lhasa apso and Shih Tzu dogs.J Am Vet Med Assoc180:
658–664,
1982
30.
OlmsteadMLStrafussA:
Urolithiasis associated with unilateral renal hypoplasia.J Am Anim Hosp Assoc13:
355–358,
1977
31.
RattnerWHMeyerRBernsteinJ:
Congenital abnormalities of the urinary system. IV. Valvular obstruction of posterior urethra.J Pediat63:
84–94,
1963
32.
WellingLWGranthamJJ:
Cystic and developmental diseases of the kidney.In:
The Kidney,
ed. BrennerRector,
3rd ed.,
vol. II,
pp. 1341–1376.
WB Saunders Co,
Philadelphia,
1986
33.
ZayedIGopinathCHornstraHWSpitBJVDHeijdenCA:
A light and electron microscopical study of glomerular lipidosis in beagle dogs.J Comp Pathol86:
509–517,
1976
