Spontaneously occurring anterior corneal opacities were present in related, juvenile American Dutch belted rabbits. Slit lamp biomicroscopy revealed focal opacities of epithelium, basement membrane, and subepithelial corneal stroma. Lesions were characterized histologically by thin and disorganized surface epithelium, thickened and intensely staining epithelial basement membrane, fimbriated and irregular basement membrane-stromal juncture, and disorganized subepithelial stroma. Biomicroscopic and histopathologic features of anterior corneal dystrophy of American Dutch belted rabbits appear similar to those of human anterior corneal dystrophies.
References
1.
AkiyaSBrownSI:
The ultrastructure of Reis-Bucklers' dystrophy.Am J Ophthamol72:
549,
1971
2.
BloomWFawcettDW:
Epithelium. In:
A Textbook of Histology,
10th ed.,
p. 96.
WB Saunders,
Philadelphia,1975
3.
BrownNABronAJ:
Recurrent erosion of the cornea.Br J Ophthalmol60:
84,
1976
4.
CoganDGDonaldsonDDKuwabaraTMarshallD:
Microcystic dystrophy of the corneal epithelium.Trans Am Ophthalmol Soc62:
213,
1965
5.
CoganDGKuwabaraT:
Ocular changes in experimental hypercholesterolemia.Arch Ophthalmol61:
219,
1959
6.
CrispinSMBarnettKC:
Arcus lipoides corneae secondary to hypothyroidism in the Alsation.J Small Anim Prac29:
127,
1978
DicePF:
Corneal dystrophy in the Airedale. Proc Am Coll Vet Ophthalmol,
p. 80.
5th Ann Scientific Pgm, Dallas,
1974
9.
DicePF:
Corneal dystrophy in the Shetland sheepdog.
Proc Am Coll Vet Ophthalmol,
p. 241.
15th Ann Scientific Pgm, Atlanta,
1984
10.
EkinsMBSquoutasDSWaringGOKanesGJ:
Oval lipid stromal opacities in beagles: VI. Quantitation of excess stromal cholesterol and phospholipid.Exp Eye Res36:
279,
1983
11.
EkinsMBWaringGOHarrisRR:
Oval lipid corneal opacities in beagles: Part II. Natural history over four years and study of tear function.J Am Anim Hosp Assoc16:
601,
1980
GwinRMGelattKN:
Bilateral ocular lipidosis in a cottontail rabbit fed an all-milk diet.J Am Med Assoc171:
887,
1977
14.
HarringtonGAKellyDF:
Corneal lipoidosis in a dog with bilateral thyroid carcinoma.Vet Pathol17:
490,
1980
15.
HaskinsMEJezykPFDesnickRJMcDonoughSKPattersonDF:
Mucopolysaccharidosis in a domestic short-haired cat-a disease distinct from that seen in the Siamese cat.J Am Vet Med Assoc175:
384,
1979
16.
HoganMJAlvaradoJAWeddellJS:
The cornea. In:
Histology of the Human Eye,
chap. 3,
p. 65.
WB Saunders,
Philadelphia,1971
17.
JanesRG:
Changes in the rabbit's eye caused by cholesterol feeding.Am J Ophthalmol58:
819,
1964
18.
KenyonKRFogleJAStoneDL:
Degeneration of corneal epithelial basement membrane following thermal cauterization.Invest Ophthalmol Vis Sci16:
292,
1977
19.
KhodadoustAASilversteinAMKenyonKR:
Adhesions of regenerating corneal epithelium.Am J Ophthalmol65:
339,
1968
20.
KuwabaraTCiccarelliEC:
Meesman's corneal dystrophy: a pathological study.Arch Ophthalmol71:
676,
1964
21.
LangweilerMHaskinsMEJezykPF:
Mucopolysaccharidosis in a litter of cats.J Am Anim Hosp Assoc14:
748,
1978
22.
LatimerCAWymanMHamiltonJ:
An ophthalmic survey of the neonatal horse.Equine Vet J (Suppl)2:
9,
1983
23.
MacMillanADWaringGOSpanglerWLRothAM:
Crystalline corneal opacities in the Siberian husky.J Am Vet Med Assoc175:
829,
1979
24.
MurrayJABlakemoreWFBarnettKC:
Ocular lesions in cats with GM1–gangliosidosis with visceral involvement.J Small Anim Pract18:
1,
1977
25.
PortCDDoddDC:
Two cases of corneal epithelial dystrophy in rabbits.Lab Anim Sci33:
587,
1983
26.
RiceNSCAshtonNJayB:
Reis-Bucklers' dystrophy. A clinicopathological study.Br J Ophthalmol52:
577,
1968
27.
RobertsSR:
Congenital posterior ectasia of the sclera in collie dogs.Am J Ophthalmol50:
451,
1960
28.
RoerigDLHasegawaATHarrisGJLynchKLWangRIH:
Occurrence of corneal opacities in rats after acute administration of 1-α-acetylmethadol.Toxicol Appl Pharmacol56:
155,
1980
29.
RothAMEkinsMBWaringGOGuptaLMRosenblattLS:
Oval corneal opacities in beagles: III. Histochemical demonstration of stromal lipids without hyperlipidemia.Invest Ophthalmol Vis Sci21:
95,
1981
30.
SlatterDHNelsenAWStringerJM:
Effects of experimental hyperlipoproteinemia in the canine eye.Exp Eye Res29:
437,
1979
31.
SpanglerWLWaringGOMorrinLA:
Oval lipid corneal opacities in beagles: V. Ultrastructure.Vet Pathol19:
150,
1982
32.
StockELMendelsohnADGarlanGLGhoshSO'GradyRB:
Lipid keratopathy in rabbits. An animal model.Arch Ophthalmol103:
726,
1985
TrobeJDLaibsonPR:
Dystrophic changes in the anterior cornea.Arch Ophthalmol87:
378,
1972
35.
WaringGOMuggliFMMacMillanA:
Oval corneal opacities in beagles.J Am Anim Hosp Assoc13:
204,
1977
36.
WaringGORodriguesMMLaibsonPR:
Corneal dystrophies. I. Dystrophies of the epithelium, Bowman's layer and stroma.Surv Ophthalmol23:
71,
1978
37.
YoshidaMAmemiyaTYoshidaMKawajiH:
Cornea of rhino mouse in a model of corneal dystrophy. In:
Immunology and Immunopathology of the Eye,
ed. SilversteinAMO'ConnorGR,
p. 355.
Masson,
New York,1979
