A 3-year-old Limousin cow was admitted to the University of Georgia Teaching Hospital with a history of chronic weight loss and diarrhea of more than 1 year's duration. Clinical laboratory findings included proteinuria and hypoproteinemia and were suggestive of a nephrotic-like syndrome. Necropsy findings included generalized edema of the visceral organs and diffuse red glistening foci on the capsular and cut surfaces of the cortex of both kidneys. Microscopically, the kidney had hypercellular and hypersegmented glomeruli, focal glomerulosclerosis, periglomerular fibrosis, and tubular nephrosis. The glomerular hypercellularity was confirmed by electron microscopy to be due to increased mesangial cells.
References
1.
AngusKWGardinerACMorganKTGrayEW:
Mesangiocapillary glomerulonephritis in lambs. II. Pathological findings and electron microscopy of the renal lesions.
J Comp Pathol84:
319,
1974.
2.
BanksKLHensonJBMcGuireTC:
Immunologically mediated glomerulitis of horses. I. Pathogenesis in persistent infection by equine infectious anemia virus.
Lab Invest26:
701,
1972.
3.
ChungJ:
Renal Disease: Classification and Atlas of Glomerular Disease,
p. 57.
Igaku-Shoin,
Tokyo, New York,
1982.
4.
CouserWGSteinmullerDRStilmanNMSulantDJLowensteinLM:
Experimental glomerulonephritis in the isolated perfused rat kidney.
J Clin Invest62:
1275,
1978.
5.
CouserWGSulantD:
In situ immune complex formation and glomerulus injury.
Kidney Int17:
1,
1980.
6.
CutlipRCMcClurkinAWCoriaMF:
Lesions in clinically healthy cattle persistently infected with the virus of bovine viral diarrhea-glomerulonephritis and encephalitis.
Am J Vet Res41:
1938,
1980.
7.
Dibos-KovacsM:
Chronic diffuse membranoproliferative glomerulonephritis and its complications in a horse.
Magyor Allatorvosok Lapju36:
533,
1981.
8.
GermuthFGJrRodriguezELorelleCATrumpEIMilanoLWiseO:
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease: I. High avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits.
Lab Invest41:
360,
1979.
9.
GermuthFGJrRodriguezELorelleCATrumpEIMilanoLWiseO:
Passive immune complex glomerulonephritis in mice: models for various lesions found in disease: II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits.
Lab Invest41:
366,
1979.
10.
HankenstudAOStrikerGMannikM:
The glomerular deposition of a soluble immune complexes prepared with reduced and alkylated antibodies and with intact antibodies in mice.
Lab Invest35:
293,
1976.
11.
JohnsonRJamisonK:
Amyloidosis in six dairy cows.
J Am Vet Med Assoc185:
1538,
1984.
12.
JonesTCHuntRD:
Veterinary Pathology,
5th ed.,
p. 1464.
Lea and Febiger,
Philadelphia,
1983.
13.
LanghornRFHallmanEI:
The incidences of glomerulonephritis in domestic animals.
J Am Vet Med Assoc99:
471,
1981.
14.
LernerRADixonFJLeeS:
Spontaneous glomerulonephritis in sheep. II. Studies on natural history, occurrence in other species and pathogenesis.
Am J Pathol53
(4):501,
1968.
15.
MaxieMG:
The urinary system.
In:
Veterinary Pathology,
ed. JubbKVFKennedyPCPalmerN,
3rd ed.,
p. 367.
Academic Press,
New York,
1985.
16.
McClauslandIPMilestoneBA:
Diffuse mesangioproliferative glomerulonephritis in a horse.
NZ Vet J24:
239,
1976.
17.
McCluskeyRTBenacerrafBPotterJMillerF:
The pathologic effects of intravenously administered soluble antigen-antibody complexes: I. Passive serum sickness in mice.
J Exp Med111:
181,
1960.
Van DamneJFleurenGBakkerWVernierRHoedemakerP:
Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens: V. Fixed glomerulus antigens in the pathogenesis of heterologous immune complex glomerulonephritis.
Lab Invest38:
502,
1978.
24.
WalkerP:
Diffuse mesangial hypercellularity in nephrotic syndrome, renal biopsy II, review and update,
p. 119.
University of Texas Health Science Center at Dallas, Department of Pathology,
1983.
25.
WilsonCBNealeTJHoldsworthSRWardDM:
Renal diseases.
In:
Basic and Clinical Immunology,
ed. FudenbergHHStitesDPCaldwellJLWellsJV,
3rd ed.,
p. 577,
1980.
26.
WisemanASpencerAPetrieL:
The nephrotic syndrome in a heifer due to glomerulonephritis.
Res Vet Sci28:
325,
1980.
