Spontaneous thymic lesions were investigated in Wistar (Cpb:WU) rats. Thymic tumors were not uncommon and most showed medullary differentiation. Thymic involution was investigated in a limited group of animals in which the survival rate for males and females was similar. The histological pattern of thymic involution differed between sexes. Severe thymic involution occurred more frequently in males than in females and at an earlier age.
References
1.
AbbottDPCherryCP:
Malignant mixed thymic tumor with metastases in a rat.Vet Pathol19:
721,
1982
2.
BeemsRBWoutersenRATilHP:
Background pathology of the Cpb:WU (Wistar Random) Rat: 3 month study.CIVO-TNO report V.82:
014,
1982
3.
BesedowskyHOSorkinE:
Thymus involvement in female sexual maturation.Nature249:
356,
1974
4.
BlairJTThomsonAWWhitingPHDavidsonRJLSimpsonJG:
Toxicity of the immune suppressant cyclosporin A in the rat.J Pathol138:
163,
1982
5.
BurekJD:
Pathology of Aging Rats.
CRC Press,
West Palm Beach,
p. 1,
1978
6.
CherryCPEinsensteinRGlücksmannA:
Epithelial cords and tubules of the rat thymus: effects of age, sex, castration, of sex, thyroid and other hormones on their incidence and secretory activity.Br J Exp Pathol48:
90,
1967
7.
FabrisNGiuntaSMuzzoiliM:
Decline of thymus-cell potential in diabetic and aged men.J Gerontol38:
549,
1983
8.
GoodmanDGWardJMSquireRAChuKCLinhartMS:
Neoplastic and non-neoplastic lesions in aging F344 rats.Toxicol Appl Pharmacol48:
237,
1979
9.
GreavesPFacciniJH:
Haemopoietic and lymphatic systems.In:
Rat Histopathology,
p. 35.
Elsevier,
Amsterdam,
1984
10.
IsohashiFTsukanakaKTeradaMTaniSSakamotoY:
Aminotransferase activities and involution of the thymus in rats bearing AH 130 tumors.Cancer Res40:
877,
1980
KroesRGarbis-BerkvensJMde VriesTvan NesselrooyJHJ:
Histopathological profile of a Wistar rat stock including a survey of the literature.J Gerontol36:
259,
1981
13.
KruisbeekAMZijlstraSPMeihuizenSPBurekJD:
Comparison between age-related changes in thymus morphology and thymus-dependent immune functions in WAG/Rij rats.
Annual report of the REP Institutes of the Organization for Health Research TNO. Rijswijk (ZHO), The Netherlands,
p. 293,
1976
14.
KruisbeekAM:
Thymus dependent immune competence.
Thesis, Utrecht, The Netherlands, 1978
15.
Lintern-MooreSPantelourisEM:
Ovarian development in athymic nude mice. 1. The size and composition of follicle population.Mech Ageing Devel4:
385,
1976
16.
MacKawaAOdaShimaS:
Spontaneous tumors in ACI/N rats.J Natl Cancer Inst55:
1437,
1975
17.
MakinodanT:
Control of immunologic abnormalities associated with aging.Mech Ageing Devel9:
7,
1979
18.
PierpaoliWBesedowskyHO:
Role of the thymus in programming of neuroendocrine functions.Clin Exp Immunol20:
323,
1975
19.
RosaiRLevineGD:
Tumors of the thymus. In:
Atlas of Tumor Pathology,
2nd series, fasc. 13,
Armed Forces Institute of Pathology,
Washington, DC,
1976
20.
RosenmannEAdlerJHUngarH:
Spontaneous thymic tumors in the fat sand rat (Psammomys obesus).J Comp Pathol92:
348,
1982
21.
RossMAKorenchevskyV:
The thymus of the rat and sex hormones.J Pathol Bacteriol52:
349,
1941
22.
SeinenWWillemsMI:
Toxicity of organotin compounds. 1. Atrophy of thymus and thymus-dependent lymphoid tissue in rats fed di-n-octyltindichloride.Toxicol Appl Pharmacol35:
63,
1976
23.
ShalhoubRJ:
Pathogenesis of lipoid nephrosis. A disorder of T cell function.Lancet2:
556,
1974
24.
SherSP:
Tumors in control hamsters, rats and mice: literature tabulation.CRC Crit Rev Toxicol10:
49,
1982
25.
SiegelS:
Nonparametic Statistics for the Behavioral Sciences,
p. 201.
McGraw-Hill Kogakusha, LTD,
Tokyo,
1956
26.
SimuGKiricutaICriviiMSNestorD:
Different behaviour of thymus in hosts bearing skin homografts of Ehrlich ascites carcinoma.Arch Geschwulstforsch46:
183,
1976
27.
SolleveldHA:
Praomys (Mastomys) natalensis in aging research.
Thesis, Utrecht, The Netherlands, 1981
28.
StimsonWHHunterIC:
Oestrogen-induced immunoregulation mediated through the thymus.J Clin Lab Immunol4:
27,
1980
29.
SuciuDUrayZ:
Cell proliferation in the thymus of Ehrlich ascites tumor bearing mice.Neoplasma26:
275,
1979
30.
SvendsenUG:
The importance of the thymus for hypertension and hypertensive vascular disease in rats and mice.Acta Pathol Microbiol Scand267:
4,
1978
VosJG:
Immune suppression as related to toxicology.CRC Crit Rev Toxicol5:
67,
1977
33.
WardJMHamlinMHAckermanLJLattuadaCPLongfellowDGCameronTP:
Age-related neoplastic and degenerative lesions in aging male virgin and exbreeder ACI/segHapBR rats.J Gerontol38:
538,
1983
