Seven dogs had one or more asymptomatic nodules, papules, or plaques on the skin or oral mucosa. The primary histologic feature was the accumulation of excess mucin within the dermis or submucosa. Based upon the clinical presentation and the histopathologic changes, it was proposed that these lesions represent the canine analogue of focal mucinosis in man, and that the same name be applied to the lesion in dogs. The criteria for the diagnosis of focal mucinosis were: (1) the presence of a single (rarely multiple) papule, nodule, or plaque which may be firm, rubbery, or soft, (2) the accumulation of mucin which disrupts and separates collagen fibers, (3) mild to extensive fibroblast proliferation, and (4) a mild mononuclear cell infiltration. The mucinoses of man and animals were reviewed.
BelcherRWClevelandMD:
Ultrastructure of the skin in the genetic mucopolysaccharidoses.
Arch Pathol94;
511,
1972
3.
ChandaJJ:
Scleromyxedema.
Cutis24;
549,
1979
4.
CoskeyRJMehreganA:
Papular mucinosis.
Int J Dermatol16;
741,
1977
5.
FamerERHambrickGWShulmanLE:
Papular mucinosis. A clinicopathologic study of four patients.
Arch Dermatol118;
9,
1982
6.
GammonWRCaroILongJCWheelerCE:
Secondary cutaneous mucinosis with systemic lupus erythematosus. A case presentation and review of the literature.
Arch Dermatol114;
432,
1978
7.
GrahamJHJohnsonWCHelwigEBeds.:
Dermal Pathology,
p. 757.
Harper & Row.
Baltimore,
1972
JonesTCHuntRD:
Veterinary Pathology,
p. 59.
Lea & Febiger,
Philadelphia,
1983
15.
KitamuraWMatsuokaYMiyagawaSSakamotoK:
Immunochemical analysis of the monoclonal paraprotein in scleromyxedema.
J Invest Dermatol70;
305,
1978
16.
KocsardEMunroVF:
Reticular erythematous mucinosis (REM syndrome) of Steigleder: its relationship to other mucinoses and to chronic erythemata.
Australas J Dermatol19;
121,
1978
17.
KovaryPMVakilzadehFMacherEZaunHMerkHGoerzG:
Monoclonal gammopathy in scleredema. Observations in three cases.
Arch Dermatol117;
536,
1981
18.
LeverWFSchaumberg-LeverG:
Histopathology of the Skin,
p. 404.
JB Lippincott Company.
Philadelphia,
1975
19.
LumD:
Cutaneous mucinosis of infancy.
Arch Dermatol116;
198,
1980
20.
MartinSLCapenCC:
Hypothyroidism and the skin.
In:
Clin North Am (Small Anim Pract).
ed. MullerGH,
vol. 9,
p. 29,
1979
21.
MullerGHKirkRWScottDW:
Small Animal Dermatology.
3rd ed.,
p. 181.
WB Saunders Company.
Philadelphia,
1983
22.
RojkoJLHooverEAMartinSL:
Histologic interpretation of cutaneous biopsies from dogs with dermatologic disorders.
Vet Pathol15;
579,
1978
23.
SchaefferDBruceSRosenT:
Cutaneous mucinosis associated with thyroid dysfunction.
Cutis32;
449,
1983
24.
ScottDW:
Histopathologic findings in the endocrine skin disorders of the dog.
J Am Anim Hosp Assoc18;
173,
1982
25.
ShapiroCMFretzinDNorrisS:
Papular mucinosis.
J Am Med Assoc214;
2052,
1970
TomichCE:
Oral focal mucinosis. A clinicopathologic and histochemical study of eight cases.
Oral Surg38;
714,
1974
28.
ValenzuelaRBergfeldWFDeodharSD:
Interpretation of Immunofluorescent Patterns in Skin Diseases,
p. 144.
American Society of Clinical Pathologists Press,
Chicago,
1984
29.
WortsmanJDietrichJIraycoffRBStoneS:
Preradial myxedema in thyroid disease.
Arch Dermatol177;
635,
1981
