Disseminated Aspergillus terreus infection was diagnosed in ten previously healthy adult dogs—nine German shepherds and one dalmatian. The disease was characterized by the presence of multiple granulomas and infarcts in a wide range of organs. The kidney, spleen, and skeletal system were most commonly and severely affected. Fungal hyphae were demonstrated in large numbers within granulomas and thrombi, and A. terreus was readily isolated by culture. This disseminated mycosis appears unique; in this series of cases there was no apparent predisposing factor, portal of entry, or primary focus for dissemination of the infection.
References
1.
AinsworthG.C.AustwickP.K.C.:
A survey of animal mycoses in Britain: General aspects.
Vet Rec67:
88–97,
1955.
2.
AscahK.J.HylandR.H.HutcheonM.A.UrbanskiS.J.PruzanskiW.St. LouisE.L.JonesD.P.KeystoneE.C.:
Invasive aspergillosis in a “healthy” patient.
Can Med Assoc J131:
332–336,
1984.
3.
BanksW.J.:
Applied Veterinary Histology,
pp. 254–276, 424–438.
Williams and Wilkins, Baltimore, London,
1981.
4.
BarrettR.E.HofferR.E.SchultzR.D.:
Treatment and immunological evaluation of three cases of canine aspergillosis.
J Am Anim Hosp Assoc13:
328–334,
1977.
5.
BlackL.NightingaleJ.P.:
Aspergillus fumigatus infection in the nasal cavity of a dog: Its treatment with amphotericin B.
Vet Rec92:
447–450,
1973.
6.
CadwalladerJ.A.GouldenB.E.BaxterM.WyburnR.S.AlleyM.R.:
Rhinitis and sinusitis involving Aspergillus fumigatus in a dog.
NZ Vet J21:
229–233,
1973.
7.
CaywoodD.WallaceL.BradenT.:
Osteomyelitis in the dog — a review of 67 cases.
J Am Vet Med Assoc172:
943–946,
1978.
8.
ChandlerE.A.:
Aspergillus infection of the nasal cavity of the dog: Diagnosis and treatment.
Vet Rec96:
156,
1975.
9.
ChusidM.J.SohnleP.G.FinkJ.N.SheaM.L.:
A genetic defect of granulocyte oxidative metabolism in a man with disseminated aspergillosis.
J Lab Clin Med97:
730–738,
1981.
10.
CordesD.O.ShortridgeE.H.:
Systemic phycomycosis and aspergillosis of cattle.
NZ Vet J16:
65–80,
1968.
11.
DavisC.L.SchaefferW.B.:
Cutaneous aspergillosis in a cow.
J Am Vet Med Assoc141:
1339–1343,
1962.
12.
DawsonC.O.BakerG.J.MackeyL.J.:
Aspergillosis of the nasal passage in a dog with tonsilar carcinoma.
Vet Rec93:
222–224,
1973.
13.
DayM.J.EgerC.E.ShawS.E.PenhaleW.J.:
Immunologic study of systemic aspergillosis in German Shepherd dogs.
Vet Immunol Immunopathol,
in press,
1985.
14.
DobbsB.B.DawsonJ.W.:
The microcirculation of the mammalian lymph node.
Lymphology9:
155–157,
1976.
GuptaB.N.:
Pulmonary aspergilloma in a rat.
J Am Vet Med Assoc173:
1196–1197,
1978.
17.
HammondW.P.DaleD.C.:
Cyclic hematopoiesis in Gray Collie dogs. In:
Immunologic Defects in Laboratory Animals,
ed. GershwinMerchant,
pp. 119–136.
Plenum Press, New York, London,
1981.
18.
IsounT.T.:
Disseminated aspergillosis in a dog.
J Niger Vet Med Assoc4:
45–48,
1975.
19.
JohnstonR.B.NewmanS.L.:
Chronic granulomatous disease.
Pediatr Clin North Am24:
365,
1977.
20.
KhooJ.K.SugaiK.LeongT.K.:
Disseminated aspergillosis: Case report and review of the world literature.
Am J Clin Pathol45:
697–703,
1965.
21.
KotharyM.H.ChaseT.MacmillanJ.D.:
Correlation of elastase production by some strains of Aspergillus fumigatus with ability to cause pulmonary invasive aspergillosis in mice.
Infect Immun32:
320–325,
1984.
22.
KrishnaL.KulshresthaS.B.PaliwalO.P.:
Systemic aspergillosis in lambs.
Indian Vet Med J5:
70–73,
1981.
LahamM.N.CarpenterJ.L.:
Aspergillus terreus, a pathogen capable of causing infective endocarditis, pulmonary mycetoma and allergic bronchopulmonary aspergillosis.
Am Rev Respir Dis125:
769–772,
1982.
25.
LaneG.Clayton-JonesD.G.ThodayK.L.ThomsettL.R.:
The diagnosis and successful treatment of Aspergillus fumigatus infection of the frontal sinuses and nasal chambers of the dog.
J Small Anim Pract15:
79–87,
1974.
26.
LazarusG.M.NeuH.C.:
Agents responsible for infection in chronic granulomatous disease of childhood.
J Pediatr86:
415–417,
1975.
27.
McCauslandI.P.:
Systemic mycoses of two cats.
NZ Vet J20:
10–12,
1971.
28.
MarksD.L.:
Systemic aspergillosis in a dog.
Canine Pract10:
49–52,
1983.
29.
MullaneyT.P.LevinS.IndrieriR.J.:
Disseminated aspergillosis in a dog.
J Am Vet Med Assoc182:
516–518,
1983.
30.
PaganiA.SpallaF.FerrariF.A.DuseM.LensiL.BretzU.BaggioliniM.SiccardiA.G.:
Defective Aspergillus killing by neutrophil leucocytes in a case of systemic aspergillosis.
Clin Exp Immunol43:
201–207,
1981.
31.
PeetR.L.RobertsonI.E.:
Suspected aspergillosis in a dog.
Aust Vet J52:
539–540,
1976.
32.
PoreS.R.LarschH.W.:
Aleuriospore formation in four related Aspergillus species.
Mycologia59:
318–325,
1967.
33.
PoreR.S.LarshH.W.:
Experimental pathology of Aspergillus terreus — flavipes group species.
Sabouraudia6:
89–93,
1968.
34.
RaperK.B.FennellD.I.:
The Genus Aspergillus,
pp. 567–577.
Williams and Wilkins, Baltimore,
1965.
35.
RenshawH.W.ChatburnCBryanG.M.BartschR.C.DavisW.C.:
Canine granulocytopathy syndrome: Neutrophil dysfunction in a dog with recurrent infections.
J Am Vet Med Assoc166:
443–447,
1975.
RipponJ.W.AndersonD.N.Soo HooM.:
Aspergillosis: Comparative virulence, metabolic rate, growth rate and ubiquinone content of soil and human isolates of Aspergillus terreus.
Sabouraudia12:
157–161,
1971.
38.
SauterJ.H.SteeleD.S.HenryJ.F.:
Aspergillosis in a cat.
J Am Vet Med Assoc127:
518–519,
1955.
39.
SchaffnerA.:
Acquired immune deficiency syndrome: Is disseminated aspergillosis predictive of underlying cellular immune deficiency.
J Infect Dis149:
828–829,
1984.
40.
SchaffnerA.DouglasH.BraudeA.:
Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes.
J Clin Invest69:
617–631,
1982.
41.
SchaffnerA.DouglasH.BraudeA.I.DavisC.E.;
Killing of Aspergillus spores depends on the anatomical source of the macrophage.
Infect Immun42:
1109–1115,
1983.
SharmaS.D.RaiP.:
Studies on the incidence of bovine mastitis in Uttar Pradish II. Sublinical mastitis.
Indian Vet J54:
435–439,
1977.
44.
StukerG.EhrenspergerF.PohlenzJ.TrollC:
Significance and diagnosis of fungal abortion in cattle.
Zentralbl Veterinaermed [B]26:
184–194,
1979.
45.
ThodayK.L.:
Aspergillus infection of the nasal cavity of the dog.
Vet Rec96:
323–324,
1975.
46.
ThurstonJ.R.CysewskiS.J.RichardJ.L.:
Exposure of rabbits to spores of Aspergillus fumigatus or Penicillium sp: Survival of fungi and microscopic changes in the respiratory and gastrointestinal tract.
Am J Vet Res40:
1443–1449,
1979.
47.
TraceyS.L.McGinnisM.R.PeacockJ.E.CohenM.S.WalkerD.H.:
Disseminated infection by Aspergillus terreus.
Am J Clin Pathol80:
728–733,
1983.
48.
WeitkampR.A.:
Aspergilloma in two dogs.
J Am Anim Hosp Assoc18:
503–506,
1982.
49.
WoodG.L.HirschD.C.SelcerR.R.RinaldiM.G.BoormanG.A.:
Disseminated aspergillosis in a dog.
J Am Vet Med Assoc172:
704–707,
1978.
50.
YoungR.C.BennettJ.E.VogelC.L.:
“Aspergillosis,” the spectrum of disease in 98 patients.
Medicine49:
147–173,
1970.
51.
ZimmermanL.E.:
Fatal fungal infections complicating other diseases.
Am J Clin Pathol25:
46–65,
1955.
