In canine mammary carcinomas, amyloid was present as amyloid-containing corpora amylacea and as local deposits between neoplastic epithelial cells or in stromal tissue. Histochemical staining methods revealed that this amyloid was not of the AA-type amyloid and contained tryptophan. The possible pathogenesis of this amyloid deposition is discussed.
References
1.
AllsopD.LandonM.KiddM.:
The isolation and amino acid composition of senile plaque core protein.Brain Res259:
348–352,
1983
2.
ArnoldJ.P.WeberA.F.:
Occurrence and fate of corpora amylacea in the bovine udder.Am J Vet Res38:
879–881,
1977
3.
BaptistS.J.ThomasJ.A.KothareS.N.:
Hyaline material in mammary cancer. A study of five cases.Indian J Cancer10:
317–321,
1973
4.
BattagliaS.TrentiniG.P.:
Aortenamyloidose im Erwachsenenalter.Virchows Arch [Pathol Anat]378:
153–159,
1978
5.
BeemsR.B.GruysE.SpitB.J.:
Amyloid in the corpora amylacea of the rat mammary gland.Vet Pathol15:
347–352,
1978
6.
BieseltR.StanullaH.:
Die isolierte tumorförmige Amyloidose der Lunge.Zentralbl Chir106:
1556–1562,
1981
7.
BlathR.A.BucyJ.G.:
Localised primary amyloidosis of the bladder.Br J Urol48:
219–220,
1976
8.
BuchnerA.DavidR.:
Amyloid-like material in odontogenic tumors.J Oral Surg34:
320–323,
1976
9.
CarstensP.H.B.HuvosA.G.FooteF.W.Jr.AshikariR.:
Tubular carcinoma of the breast: A clinicopathologic study of 35 cases.Am J Clin Pathol58:
231–238,
1972
10.
CettiR.ReutherK.Hart HansenJ.P.SchiωdtT.:
Amyloid tumor of the breast.Dan Med Bull30:
34–35,
1983
11.
CohenA.S.ShirahamaT.SipeJ.D.SkinnerM.:
Amyloid proteins, precursors, mediator, and enhancer.Lab Invest48:
1–4,
1983
12.
CohenD.H.FeinerH.JenssonO.FrangioneB.:
Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastro-enteropancreatic neuroendocrine protein gamma trace.J Exp Med158:
623–628,
1983
13.
CornwellG.G.IIIWestermarkP.MurdochW.PitkänenP.:
Senile aortic amyloid. A third distinctive type of age-related cardiovascular amyloid.Am J Pathol108:
135–139,
1982
14.
CornwellG.G.IIIWestermarkP.NatvigJ.B.MurdochW.:
Senile cardiac amyloid: Evidence that fibrils contain a protein immunologically related to prealbumin.Immunology44:
447–452,
1981
15.
DahmeE.SprenglerB.:
Weitere Uberlegungen zur Pathogenese des Altersamyloids in Meninx- und Hirnrindenarterien beim Hund.Berl Münch Tieraerztl Wschr89:
64–67,
1976
16.
DavidR.BuchnerA.:
Amyloid stroma in a tubular carcinoma of palatal salivary gland. A histochemical and ultrastructural study.Cancer41:
1836–1844,
1978
17.
DavidR.HissY.:
Corpora amylacea in mesothelioma of the atrioventricular node.J Pathol124:
111–116,
1978
18.
DillG.S.Jr.StookeyJ.L.WhitneyG.D.:
Nodular amyloidosis in the trachea of a dog.Vet Pathol9:
238–242,
1972
19.
ErnstE.SchneiderP.TrautweinG.:
Elektronenmikroskopische Untersuchungen über die Amyloidose der Atrioventrikularklappen des Hundes.Beitr Pathol152:
361–382,
1974
20.
FernandezB.B.HernandezF.J.:
Amyloid tumor of the breast.Arch Pathol95:
102–105,
1973
21.
FranklinC.D.MartinM.V.ClarkA.SmithC.J.HindleM.O.:
An investigation into the origin and nature of “amyloid” in a calcifying epithelial odontogenic tumour.J Oral Pathol10:
417–429,
1981
22.
GlennerG.G.:
Amyloid deposits and amyloidosis. The β-fibrilloses.N Engl J Med302:
1283–1292,
1333–1343,
1980
23.
GlennerG.G.CostaP.P.de FreitasF.:
Amyloid and amyloidosis.
Proc. Third Intl. Symp. on Amyloidosis,
pp. XI–XII.
Excerpta Medica, Amsterdam,
1980
24.
GruysE.:
A comparative approach to secondary amyloidosis. Minireview.Dev Comp Immunol3:
23–36,
1979
25.
GruysE.TimmermansH.J.F.:
Diagnosis of secondary amyloid in bovine renal amyloidosis.Vet Sci Comm3:
21–37,
1979
26.
HacihanefiogluU.UzgörenE.:
Amyloid producing tumour of the lung.Thorax36:
395–396,
1981
27.
HampeJ.F.MisdorpW.:
Tumours and dysplasias of the mammary gland.Bull WHO50:
111–133,
1974
28.
HanssonC.G.Säve-SöderberghJ.NilssonO.:
Corpora amylacea in parathyroids in cases of primary hyperparathyroidism.Pathol Europ9:
151–158,
1974
29.
HardyT.J.MyerowitzR.L.BenderB.L.:
Diffuse parenchymal amyloidosis of lungs and breast. Its association with diffuse plasmacytosis and K-chain gammopathy.Arch Pathol Lab Med103:
583–585,
1979
HeadK.W.:
Tumours of the upper alimentary tract.Bull WHO53:
145–166,
1976
32.
HiguchiK.MatsumuraA.HonmaA.TakeshitaS.HashimotoK.HosokawaM.YasuhiraK.TakedaT.:
Systemic senile amyloid in senescence-accelerated mice. An unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method.Lab Invest48:
231–240,
1983
33.
JakobW.:
Untersuchungen über die Altersamyloidose der Katze.Zentralbl Veterinaermed [A]17:
261–272,
1970
34.
JakobW.:
Untersuchungen über die Amyloidose der Karnivoren unter besonderer Berücksichtigung der Altersamyloidose.Zentralbl Veterinaermed [A]17:
818–829,
1970
35.
KumakiriM.HashimotoK.:
Histogenesis of primary localized cutaneous amyloidosis: Sequential change of epidermal keratinocytes to amyloid via filamentous degeneration.J Invest Dermatol73:
150–162,
1979
36.
KumakiriM.HashimotoK.TsuhinagaI.KimuraT.MiuraY.:
Presence of basal lamina-like substance with anchoring fibrils within the amyloid deposits of primary localized cutaneous amyloidosis.J Invest Dermatol81:
153–157,
1983
37.
LinkeR.P.:
Immunohistochemical identification and crossreactions of amyloid fibril proteins in senile heart and amyloid in familial polyneuropathy. Lack of reactivity with cerebral amyloid in Alzheimer's disease.Clin Neuropathol1:
172–182,
1982
38.
LinkeR.P.HolP.R.GruysE.GeiselO.NathrathW.B.J.TrautweinE.:
Immunohistochemical identification and crossreactions of amyloid-A fibril proteins in man, mouse, hamster, guinea pig, rabbit, cat, dog, stone marten, pince marten, cow and horse.J Comp Pathol94:
339–356,
1984
39.
LipperS.KahnL.B.:
Amyloid tumor. A clinicopathologic study of four cases.Am J Surg Pathol2:
141–145,
1978
40.
McLellanG.L.StewartJ.H.BalachandranS.:
Localization of Tc-99m-MDP in amyloidosis of the breast.Clin Nucl Med6:
579–580,
1981
41.
MaedaH.OhtaS.SaitoY.NamekiH.IshikawaH.:
Epidermal origin of the amyloid in localized cutaneous amyloidosis.Br J Dermatol106:
345–351,
1982
42.
MatsumuraA.HiguchiK.ShimizuK.HosokawaM.HashimotoK.YasuhiraK.TakedaT.:
A novel amyloid fibril protein isolated from senescence-accelerated mice.Lab Invest47:
270–275,
1982
43.
MatthiasD.JakobW.:
Untersuchungen über die Altersamyloidose des Hundes und ihre Stellung zur sog. Typische Amyloidose.Zentralbl Veterinaermed [A]16:
477–494,
1969
44.
MeenaghanM.A.AppelB.N.GreenG.W.Jr.:
Amyloid-containing odontogenic tumors of man.Oral Surg34:
908–919,
1972
45.
MelatoM.ManconiR.FalconieriG.:
Amyloidosis and lung cancer. A morphological and histochemical study.Morphol Embryol [Bucar]27:
137–142,
1981
46.
NorenP.WestermarkP.CornwellG.G.IIIMurdochW.:
Immunofluorescence and histochemical studies of localized cutaneous amyloidosis.Br J Dermatol108:
277–285,
1983
47.
PatilS.D.JoshiB.G.DatarK.G.:
Amyloid deposit in the carcinoma of breast. A case report.Indian J Cancer7:
60–62,
1970
48.
PatnaikA.K.LiebermanP.H.ErlandsonR.A.AcevedoW.M.LiuS-k.:
Canine medullary carcinoma of the thyroid.Vet Pathol15:
590–599,
1978
49.
PitkänenP.WestermarkP.CornwellG.G.IIIMurdochW.:
Amyloid of the seminal vesicles. A distinctive and common localized form of senile amyloidosis.Am J Pathol110:
64–69,
1983
50.
PowersJ.M.SchlaepferW.W.WillinghamM.C.HallB.J.:
An immunoperoxidase study of senile cerebral amyloidosis with pathogenetic considerations.J Neuropathol Exp Neurol40:
592–612,
1981
51.
ReidI.M.:
Corpora amylacea of the bovine mammary gland. Histochemical and electron microscopic evidence for their amyloid nature.J Comp Pathol82:
409–415,
1972
52.
van RijswijkM.H.HeusdenC.vanW.G.J.:
The potassium permanganate method. A reliable method for differentiating amyloid AA from other forms of amyloid in routine laboratory practice.Am J Pathol97:
43–58,
1979
53.
SadegheeS.A.MooreS.W.:
Rheumatoid arthritis, bilateral amyloid tumors of the breast, and multiple cutaneous amyloid nodules.Am J Clin Pathol62:
472–476,
1974
54.
SchiωdtT.JensenH.NielsenM.RanlωvP.:
On the nature of amyloid-like duct wall changes in carcinoma of the breast.Acta Pathol Microbiol Scand [A]80:
151–157,
1972
SchwalbeH-P.QuadbeckJ.:
Die Corpora amylacea im menschlichen Gehirn.Virchows Arch [Pathol Anat]366:
305–311,
1975
58.
SemanG.:
Fibrillar bodies in human prostate.Prostate4:
179–187,
1983
59.
ShirahamaT.SkinnerM.WestermarkP.RubinowA.CohenA.S.BrunA.KemperT.L.:
Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion.Am J Pathol107:
41–50,
1982
60.
StamF.C.RoukemaP.A.:
Histochemical and biochemical aspects of corpora amylacea.Acta Neuropathol [Berl]25:
95–102,
1973
61.
StokesG.:
An improved Congo red method for amyloid.Med Lab Sci33:
79–80,
1976
62.
StünziH.EhrenspergerF.WildP.LeemannW.:
Systemische Hautund Unterhautamyloidose beim Pferd.Vet Pathol12:
405–414,
1975
63.
SümegiI.RajkaG.:
Amyloid-like substance surrounding mammary cancer and basal cell carcinoma.Acta Pathol Microbiol Scand [A]80:
185–192,
1972
64.
SunC.N.:
Ultrastructural study of corpora amylacea in human thyroid gland.Exp Pathol [Jena]23:
219–225,
1983
65.
ThomsonR.G.:
General Veterinary Pathology,
pp. 40–43.
W. B. Saunders Company,
Philadelphia-London-Toronto,
1978
66.
ToygarliS.A.:
Lokale blastomatöse Amyloidose der Nasenschleimhaut beim Pferd.DTW60:
372,
1953
WestermarkP.JohanssonB.NatvigJ.B.:
Senile cardiac amyloidosis: Evidence of two different amyloid substances in the ageing heart.Scand J Immunol10:
303–308,
1979
69.
WestermarkP.ShirahamaT.SkinnerM.BrunA.CameronR.CohenA.S.:
Immunohistochemical evidence for lack of amyloid P-component in some intracerebral amyloids.Lab Invest46:
457–460,
1982
70.
WestermarkP.SlettenK.PitkänenP.NatvigJ.B.LindholmC-E.:
Localized laryngeal amyloidosis: partial characterization of an amyloid fibril protein AL.Mol Immunol19:
447–450,
1982
71.
WrightJ.R.CalkinsE.HumphreyR.L.:
Potassium permanganate reaction in amyloidosis.Lab Invest36:
274–281,
1977
72.
YanoB.C.HaydenD.W.JohnsonK.H.:
Feline insular amyloid: Incidence in adult cats with no clinicopathologic evidence of overt diabetes mellitus.Vet Pathol18:
181–187,
1981
73.
YanoB.C.HaydenD.W.JohnsonK.H.:
Feline insular amyloid: Association with diabetes mellitus.Vet Pathol18:
621–627,
1981
