During a 14-year period, carcinoma of the anal sac apocrine glands was found in 52 pastel and 8 sapphire mink (Mustela vison) kept for studies on slow viral diseases. The pastel mink varied in age from 72 to 135 months (mean age 108 months), the sapphire mink from 63 to 100 months (mean age 81 months). All but one pastel mink were females. The primary tumor varied in size from masses that caused bulges in the perineum to those that were found only after microscopic examination of the anal sac glands. Although the primary tumor grew mainly by expansion with little local infiltration, 41 of the 60 tumors had metastasized to the regional lymph nodes and sometimes also to more distant sites. The striking propensity of the carcinoma to metastasize while still small, even microscopic, often resulted in massive secondary growths, notably in the iliac lymph nodes. Hypercalcemia did not accompany the carcinoma. Its varied microscopic appearance included solid, glandular, squamous cell, and spindle or round cell components. Combinations of them formed mixed or complex histologic patterns, no doubt largely attributable to neoplastic proliferation of myoepithelial cells and squamous metaplasia of the apocrine gland epithelium. Although its cause remains obscure, the carcinoma appeared to arise from small foci of hyperplastic apocrine glands, sometimes in relation to both anal sacs. The tumor is a common and distinctive expression of neoplasia in older ranch mink.
References
1.
AfronsinM.F.:
Electron microscope study of the morphology of the secretory cells of the perianal glands of mink. I. Tubular part. II. Alveolar part.Sbornik Nauchnykh Trudov, Moskovskaya Veterinarnaya Akademiya80:
130–134,
134–140,
1975
(In Russian)
2.
AfronsinM.F.:
Myoepithelial cells in the tubular portion of the pre-anal glands in mink.Sbornik Nauchnykh Trudov, Moskovskaya Veterinarnaya Akademiya93:
99–103.
1977
(In Russian)
3.
AfronsinM.F.:
Distribution of succinate dehydrogenase and acid and alkaline phosphatases in the cells of the preanal glands of mink.Sbornik Nauchnykh Trudov, Moskovskaya Veterinarnaya Akademiya93:
103–106.
1977
(In Russian)
4.
AfronsinM.F.:
I. Glycogen content of secretory cells in alveoli of the preanal glands of mink. II. Secretory and mitochondrial activity in tubule cells of the preanal glands of mink.Sbornik Nauchnykh Trudov, Moskovskaya Veterinarnaya Akademiya102:
84–87,
88–92,
1978
(In Russian)
5.
BaginskiE.ZakB.L.:
Microdetermination of serum phosphate and phospholipids.Clin Chim Acta5:
834–838,
1960
6.
BrinckCGerellR.OdhamG.:
Anal pouch secretion in mink Mustela vison. Chemical communication in Mustelidae.Oikos30:
68–75,
1978
7.
CarpenterJ.W.DavidsonJ.P.NovillaM.N.HuangJ.C.M.:
Metastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferret.J Wildl Dis16:
587–592,
1980
8.
CarpenterJ.W.HillmanC.N.:
Husbandry, reproduction, and veterinary care of captive ferrets.
Proc Am Assoc Zoo Vet,
pp. 36–47,
1978
9.
CarpenterJ.W.NovillaM.N.:
Diabetes mellitus in a black-footed ferret.J Am Vet Med Assoc171:
890–893,
1977
10.
ChestermanF.C.PomeranceA.:
Spontaneous neoplasms in ferrets and polecats.J Pathol Bacteriol89:
529–533,
1965
11.
ChristieG.S.JabaraA.G.:
Canine sweat gland growths.Res Vet Sci5:
237–244,
1964
12.
CornogJ.L.MobiniJ.SteigerE.EnterlineH.T.:
Squamous carcinoma of the breast.Am J Clin Pathol55:
410–417,
1971
13.
CreedJ.E.KainerR.A.:
Surgical extirpation and related anatomy of anal sacs of the ferret.J Am Vet Med Assoc179:
575–577,
1981
14.
DunnT.B.:
Morphology of mammary tumors in mice. In:
Physiopathology of Cancer,
ed. Homburger,
2nd ed.,
pp. 38–84.
Hoeber,
New York,
1959
15.
EngelbartK.StrasserH.:
Squamous carcinoma in the ferret.
Blue Book,
Veterinary Profile No. 11:
28–30,
1966
16.
EwerR.F.:
The Carnivores,
pp. 90–100.
Cornell University Press,
Ithaca,
1973
17.
FouldsL.:
Neoplastic Development,
vol. 1,
pp. 142–153.
Academic Press,
New York,
1969
18.
GerischD.NeurandK.:
Topographie und Histologic der Drüsen der Regio analis des Hundes.Anat Histol Embryol2:
280–294,
1973
19.
GersellD.J.KatzensteinA.-L. A.:
Spindle cell carcinoma of the breast. A clinicopathologic and ultrastructural study.Hum Pathol12:
550–561,
1981
20.
GoldschmidtM.H.ZoltowskiC.:
Anal sac gland adenocarcinoma in the dog: 14 cases.J Small Anim Pract22:
119–128,
1981
21.
GorhamJ.R.QuortrupE.R.:
Squamous cell carcinoma in a mink.J Am Vet Med Assoc113:
245–246,
1948
22.
HadlowW.J.RaceR.E.JacksonJ.A.:
Lymphoreticular proliferative disease in mink homozygous for the Aleutian gene.JNCI49:
1455–1457,
1972
23.
HamperlH.:
The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors.Curr Top Pathol53:
161–220,
1970
24.
Jablan-PanticO.MiladinovicZ.DrekicD.:
Lymph nodes of the thoracic, abdominal and pelvic walls and viscera, of the mink. Acta.Vet (Belgrade)26:
81–93,
1976
25.
KainerR.A.:
The gross anatomy of the digestive system of the mink. II. The midgut and the hindgut.Am J Vet Res15:
91–97,
1954
26.
KeelerC.:
The detection and interaction of body size factors among ranch-bred mink.Bull Georgia Acad Sci19:
22–60,
1961
27.
KeelerCMooreL.:
Psychosomatic synthesis of behavior trends in the taming of mink.Bull Georgia Acad Sci19:
66–74,
1961
28.
LavineW.S.PageR.C.PadgettG.A.:
Host responses in chronic periodontal disease. V. The dental and periodontal status of mink and mice affected by Chediak-Higashi syndrome.J Periodontol47:
621–635,
1976
29.
LöligerH.C.:
Geschwulstbildungen beim Nerz.Berl Muench Tieraerztl Wochenschr75:
372–375,
1962
30.
LöligerH.C.:
Pelztierkrankheiten,
pp. 312–333.
Gustav Fischer Verlag,
Stuttgart,
1970
31.
McCollI.:
The comparative anatomy and pathology of anal glands.Ann Roy Coll Surg England40:
36–67,
1967
32.
MeutenD.J.CapenC.C.KocibaG.J.ChewD.J.CooperB.J.:
Ultrastructural evaluation of adenocarcinomas derived from apocrine glands of the anal sacs associated with hypercalcemia in dogs.Am J Pathol107:
167–175,
1982
33.
MeutenD.J.CooperB.J.CapenC.C.ChewD.J.KocibaG.J.:
Hypercalcemia associated with an adenocarcinoma derived from the apocrine glands of the anal sac.Vet Pathol18:
454–471,
1981
34.
MeutenD.J.SegreG.V.CapenC.C.KocibaG.J.VoelkelE.F.LevineL.TashijanA.H.Jr.ChewD.J.NagodeL.A.:
Hypercalcemia in dogs with adenocarcinoma derived from apocrine glands of anal sac. Biochemical and histomorphometric investigations.Lab Invest48:
428–435,
1983
35.
MoultonJ.E.:
Tumors of the mammary gland. In:
Tumors in Domestic Animals,
ed. Moulton,
pp. 346–371,
2nd ed.University of California Press,
Berkeley,
1978
36.
PadgettG.A.GorhamJ.R.HensonJ.B.:
Mink as a biomedical model.Lab Anim Care18:
258–266,
1968
37.
PadgettG.A.ReiquamC.W.HensonJ.B.GorhamJ.R.:
Comparative studies of susceptibility to infection in the Chediak-Higashi syndrome.J Pathol Bacteriol95:
509–522,
1968
RewellR.E.:
Multiple squamo-sebaceous carcinomas of the skin in a polecat, Putorius putorius.J Pathol Bacteriol61:
146–147,
1949
40.
RijnberkA.ElsinghorstA.M.KoemanJ.P.HackengW.H.L.LequinR.M.:
Pseudohyperparathyroidism associated with perirectal adenocarcinomas in elderly female dogs.Tijdschr Diergeneeskd103:
1069–1075,
1978
41.
SchildknechtH.WilzI.EnzmannF.GrundN.ZieglerM.:
Mustelan, the malodorous substance from the anal gland of the mink (Mustela vison) and the polecat (Mustela putorius).Angew Chem [Engl]15:
242–243,
1976
42.
ShackelfordR.M.:
Types of mink. In:
Blue Book of Fur Farming,
pp. 6,
10–12,
14–19.
Communications Marketing, Inc.,
Edina, Minnesota,
1972
43.
SokolovV.E.AlboneE.S.FloodP.F.HeapP.F.KaganM.Z.VasilievaV.S.RoznovV.V.ZinkevichE.P.:
Secretion and secretory tissues of the anal sac of the mink, Mustela vison: Chemical and histological studies.J Chem Ecol6:
805–825,
1980
44.
StubbeM.:
Zur Evolution der analen Markierungsorgane bei Musteliden.Biol Zentralbl89:
213–223,
1970
45.
StubbeM.:
Die analen Markierungsorgane der Mustela-Arten.Zool Garten (Leipzig) NF42:
176–188,
1972
46.
SymmersW. St. C.ThomsonA.P.D.:
A spontaneous carcinoma of the skin of a ferret (Mustela furo L.).J Pathol Bacteriol62:
229–233,
1950
47.
SymmersW. St. C.ThomsonA.P.D.:
Multiple carcinomata and focal mast-cell accumulations in the skin of a ferret (Mustela furo L.), with a note on other tumours in ferrets.J Pathol Bacteriol65:
481–493,
1953
48.
TravisH.F.PilbeamT.E.:
Use of artificial light and day length to alter the life cycles of mink.J Anim Sci50:
1108–1112,
1980
49.
WillisJ.B.:
The determination of metals in blood serum by atomic absorption spectroscopy: I. Calcium.Spectrochim Acta16:
259–272,
1960
