Ceroid, lipofuscin, and hyaline-type intracytoplasmic granules found in cardiac muscle cells of cynomolgus monkeys were studied using histologic, histochemical, and fluorescent microscopic techniques. The studies indicated that the ceroid granules contained an insoluble lipid as well as a component that was stainable with Luxol fast blue and Mallory's phloxine stain for hyaline. Lipofuscin granules had staining reactions characteristic of the classical age-related pigment. Hyaline granules were devoid of lipid component and were distinctly different from either ceroid or lipofuscin. All three types of granules were located at the poles of cardiac muscle cell nuclei.
References
1.
BourneG. H.:
Lipofuscin. In:
Progress in Brain Research, Neurobiological Aspects of Maturation and Aging,
ed. Ford
pp. 187–201,
vol. 40.
Elsevier Scientific Publishing Company,
Amsterdam,
1973
2.
BrizzeeK. R.OrdyJ. M.KaackB.:
Early appearance and regional differences in intraneuronal and extraneuronal lipofuscin accumulation with age in the brain of a non-human primate (Macaca mulatta).J Gerontol29:
366–381,
1974
3.
DekkerA.OehrleJ. S.:
Hyaline globules of the adrenal medulla of man.A product of lipid peroxidation? Arch Pathol91:
353–364,
1971
4.
JastyV.KowalskiR. L.FonsecaE. H.PorterM. C.ClemensG. R.BareJ. J.HartnagelR. E.:
An unusual case of generalized ceroid-lipofuscinosis in a cynomolgus monkey.Vet Pathol21:
46–50,
1984
5.
LillieR. D.FullmerH. M.:
Histopathologic Technic and Practical Histochemistry,
pp. 670–671.
McGraw-Hill Book Company,
New York,
1976
6.
McConnellE. E.TalleyF. A.:
Intracytoplasmic hyaline globules in the adrenal medulla of laboratory animals.Vet Pathol14:
435–440,
1977
7.
PallisC. A.DuckettS.PearseA. G. E.:
Diffuse lipofuscinosis of the central nervous system.Neurology (Minneap)17:
381–394,
1967
8.
PearseA. G. E.:
Histochemistry: Theoretical and Applied,
pp. 1076–1085,
vol. 2.
The Williams & Wilkins Company,
Baltimore,
1972
9.
SandritterW.ThomasC.:
Color Atlas and Textbook of Histopathology,
p. 35.
Year Book Medical Publishers,
Chicago1979
10.
StrehlerB. L.:
On the histochemistry and ultrastructure of age pigment. In:
Advances in Gerontological Research,
ed. Strehler
pp. 343–384,
vol. 1.
Academic Press,
New York,
1964
