A wide range of spontaneous tumors of the ovary are reported in a group of 5903 aged female Sprague-Dawley rats of the CD and CFY strains examined since 1978 in this laboratory. The most commonly observed tumor was the tubular adenoma. Others recorded were tubular adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, a Sertoli's cell tumor, benign and malignant granulosa cell tumors, benign thecal cell tumors, and classical mesotheliomas of ovarian origin. A system of classification and nomenclature of the ovarian tumors from this group is advanced.
AshleyD. J. B.:
Evans' Histological Appearances of Tumours,
3rd ed.,
pp. 663–672.
Churchill, Livingstone,
Edinburgh, London and New York,
1978
3.
BeilbyJ. O. W.:
Germ cell and sex-cord mesenchymal tumours of the gonads. In:
Recent Advances in Histopathology,
ed. AnthonyP. P.WolfN.,
vol. 10,
pp. 259–273.
Churchill, Livingstone,
Edinburgh, London and New York,
1978
4.
CarterR. L.:
Pathology of ovarian neoplasia in rats and mice.Br J Cancer3:
527–543,
1968
5.
CarterR. L.IrdE. A.:
Tumors of the ovary. In:
Pathology of Tumours in Laboratory Animals, vol. I: The Rat,
ed. TurusovV. S.,
pp. 189–194.
WHO International Agency for Research on Cancer,
Geneva,
1978
6.
CrainR. C.:
Sspontaneous tumours in the Rochester strain of the Wistar rat.Am J Pathol34:
311–315,
1958
7.
EngleE. T.:
Tubular adenomas and testis-like tubules in the ovaries of aged rats.Cancer Res6:
578–582,
1946
8.
FrithC. H.ZunaR. E.MorganK.:
A morphologic classification and incidence of spontaneous ovarian neoplams in three strains of mice.JNCI67:
693–702,
1981
9.
JabaraA. G.:
Induction of canine ovarian tumours by diethylstilboestrol and progesterone.Aust Exp Biol40:
139–152,
1962
10.
KingN. W.:
The reproductive tract.
In: Pathology of Laboratory Animals,
ed. BenirschkeGarnerJones
pp. 527–531.
Springer-Verlag,
New York,
1978
11.
McClureH. M.ChapmanW. L.HooperB. E.SmithG. T.FletcherO. J.:
In: Pathology of Laboratory Animals,
ed. BenirschkeGarnerJones,
pp. 290–291.
Springer-Verlag,
New York,
1978
RatcliffeH. L.:
Spontaneous tumors in two colonies of rats of the Wistar Institute of Anatomy and Biology.Am J Pathol16:
237–254,
1940
14.
RussfieldA. B.:
Pathology of endocrine glands, ovary and testis of rats and mice. In:
Pathology of Laboratory Rats and Mice,
ed. CotchinRoe,
pp. 391–468.
Blackwell Scientific Publications,
Oxford and Edinburgh,
1967
15.
SerovS. F.ScullyR. E.SobinL. H.:
Histological Typing of Ovarian Tumors,
p. 44.
World Health Organization,
Geneva,
1973
