In the early stages of large granular lymphocyte leukemia of F344 rats, splenic congestion and lymphocytic depletion of the splenic white pulp are the most significant and consistent histologic findings. The diagnosis of early leukemia was confirmed by immunocytochemical demonstration that the cell surface of leukemic large granular lymphocytes reacted with OX-8 monoclonal antibodies and by transplantation of the disease at early stages to healthy weanling rats.
References
1.
BrideauR. J.CarterP. B.McMasterW. R.MasonD. W.WilliamsA. F.:
Two subsets of rat T-lymphocytes defined with monoclonal antibodies.Eur J Immunol10:
609–615,
1980
2.
ChopraH. C.WoodsideN. S.BogdenA. E.:
Virus particles in rat leukemias.Cancer Res30:
1544–1547,
1970
3.
DaveyF. R.MoloneyW. C.:
Postmortem observations on Fischer rats with leukemia and other disorders.Lab Invest23:
327–334,
1970
4.
DunningW. F.CurtisM. R.:
A transplantable acute leukemia in an inbred line of rats.JNCI19:
845–853,
1957
5.
GrossiC. E.CadoniA.ZiciaA.LepriniA.FerrariniM.:
Large granular lymphocytes in human peripheral blood: ultrastructural and cytochemical characterization of the granules.Blood59:
277–283,
1982
6.
HsuS. M.RaineL.FangerH.:
Use of adivin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody PAP procedures.J Histochem Cytochem29:
577–580,
1981
7.
KusewittD. F.HahnF.PickerellJ. A.:
Hematologic and serum chemical characteristics of mononuclear cell leukemia in Fischer F344 rats.Lab Anim Sci32:
275–277,
1982
8.
MoloneyW. C.BoschettA. E.KingV. P.:
Observations on leukemia in Wistar Furth rats.Cancer Res29:
938–946,
1969
MoloneyW. C.KingV. P.:
Reduction of leukemia incidence following splenectomy in the rat.Cancer Res33:
573–574,
1973
11.
ReynoldsC. W.BereE. W.Jr.WardJ. M.:
Natural killer cell activity in the rat. III. Characterization of transplantable large granular lymphocyte (LGL) leukemias in the F344 rat.J Immunol132:
534–540,
1984
12.
ReynoldsC. W.SharrowS. O.OrtaldoJ. R.HerbermanR.:
Natural killer activity in the rat. II. Analysis of surface antigens on LGL by flow cytometry.J Immunol127:
2204–2208,
1981
13.
ReynoldsC. W.TimonenT.HerbermanR. B.:
Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells.
J Immunol127:
282–287,
1981
14.
ReynoldsC. W.TimonenT. T.HoldenH. T.HansenC. T.HerbermanR. B.:
Natural killer cell activity in the rat. Analysis of effector cell morphology and effects of interferon on natural killer cell function in the athymic (nude) rat.Eur J Immunol12:
577–582,
1982
15.
SchalmO. W.JainN. C.CarrollE. J.:
Veterinary Hematology,
p. 807.
Lea and Febiger,
Philadelphia,
1975
16.
StrombergP. C.RojkoJ. L.VogtsbergerL. M.CheneyC.BermanR.:
Immunologic, biochemical and ultrastructural characterization of the leukemia cell in F344 rats.JNCI71:
173–181,
1983
17.
StrombergP. C.VogtsbergerL. M.:
Pathology of the mononuclear cell leukemia of Fischer rats. I. Morphologic studies.Vet Pathol20:
698–708,
1983
18.
WardJ. M.:
Background data and variations in tumor rats of control rats and mice.Prog Exp Tumor Res26:
241–258,
1982
19.
WardJ. M.ArgilanF.ReynoldsC. W.:
Immunoperoxidase localization of large granular lymphocytes in normal tissues and lesions of athymic nude rats.J Immunol131:
132–139,
1983
20.
WardJ. M.ReynoldsC. W.:
Large granular lymphocyte leukemia, a heterogeneous lymphocytic leukemia in F344 rats.Am J Pathol111:
1–10,
1983
21.
WardJ. M.SagartzJ. W.CaseyH. W.:
Pathology of the Aging F344 Rat,
pp. 9–10.
Armed Forces Institute of Pathology,
Washington, D. C.,
1980
