Weanling PVG/c rats treated with the α-mannosidase inhibitor swainsonine developed increasing proteinuria which terminated as a severe nephrotic syndrome after 35 to 45 days. This was associated with a glomerulopathy characterized by the production of collagen fibrils adjacent to endothelial and mesangial cells, foot process expansion, subepithelial projections of the basement membrane, and splitting of the lamina densa. The swainsonine-induced glomerulopathy appeared to be an exacerbation of a spontaneous abnormality in this strain of rat.
References
1.
BernsteinJ.:
Hereditary renal disease.
In:
Kidney Disease, Present Status,
ed. ChurgJ.,
pp. 295–326.
Williams & Wilkins,
Baltimore,
1979.
2.
BoltonW.K.BentonF.R.MaclayJ.G.SturgillB.C.:
Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. Lesions associated with mesangial IgM deposits.
Am J Pathol85:
277–300,
1976.
3.
BrennerB.M.HostetterT.H.HumesH.D.:
Molecular basis of proteinurea of glomerular origin.
N Engl J Med298:
826–833,
1978.
4.
CarlsonE.C.BrendelK.MeezanE.:
Striated collagen fibrils derived from ultra-structurally pure isolated basal lamina.
In:
Biology & Chemistry of Basement Membranes.
ed. KefalidesN. A.,
pp. 31–41.
Academic Press,
New York,
1978.
5.
CaulfieldJ.P.ReidJ.J.FarquharM.G.:
Alteration of the glomerular epithelium in acute aminonucleoside nephrosis. Evidence for formation of occluding junctions and epithelial cell detachment.
Lab Invest34:
43–59,
1976.
6.
ChurgJ.:
Coagulation and the kidney.
In:
Kidney Disease. Present Status,
ed. ChurgJ.,
pp. 140–163.
Williams & Wilkins,
Baltimore,
1979.
7.
ColegateS.M.DorlingP.R.HuxtableC.R.:
A spectroscopic investigation of swainsonine: An α-mannosidase inhibitor isolated from Swainsona canescens.
Aust J Chem32:
2257–2264,
1979.
DorlingP.R.HuxtableC.R.ColegateS.M.:
Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
Biochem J191:
649–651,
1980.
10.
DorlingP.R.HuxtableC.R.VogelP.:
Lysosomal storage and Swainsona sp. toxicosis: An induced mannosidosis.
Neuropathol Appl Neurobiol4:
285–295,
1978.
11.
GrayJ.E.:
Chronic progressive nephrosis in the albino rat.
Crit Rev Toxicol5:
115–144,
1977.
12.
GrayJ.E.WeaverR.N.PurmalisA.:
Ultrastructural observations of chronic progressive nephrosis in the Sprague-Dawley rat.
Vet Pathol11:
153–169,
1974.
13.
HuxtableC.R.DorlingP.R.:
Mannosidosis: Swainsonine-induced mannosidosis.
Am J Pathol107:
124–126,
1982.
14.
JollyR.D.WinchesterB.G.GehierJ.DorlingP.R.DawsonG.:
Mannosidosis: A comparative review of biochemical and related clinico-pathological aspects of three forms of the disease.
J Appl Biochem3:
273–291,
1981.
15.
KanwarY.S.FarquharM.G.:
Presence of heparin sulphate in glomerular basement membrane.
Proc Natl Acad Sci USA76:
1303–1307,
1979.
16.
KarnovskyM.J.:
The structural basis for glomerular filtration.
In:
Kidney Disease, Present Status,
ed. ChurgJ.,
pp. 1–41.
Williams & Wilkins,
Baltimore.
1979.
17.
KefalidesN.A.:
Chemical properties of basement membranes.
Int Rev Connect Tissue Res6:
63–104,
1973.
18.
KefalidesN.A.Forsell-KnottL.:
Structural changes in the protein and carbohydrate components of glomerular basement membrane in aminonucleoside nephrosis.
Biochim Biophys Acta203:
62–66,
1970.
19.
LanniganR.BarabasA.PeterK.HardwickeJ.:
Some experimental models of the nephrotic syndrome.
Methods Achiev Exp Pathol4:
141–170,
1969.
20.
LattaM.:
Collagen in normal rat glomeruli.
J Ultrastruct Res5:
364–373,
1961.
MoritaT.LaughlinL.O.KawanoK.KimmelsteilP.SuzukiY.ChurgJ.:
Nail-patella syndrome. Light and electron microscopic studies of the kidney.
Arch Intern Med131:
271–277,
1973.
23.
OlsenR.S.:
Diabetic glomerulosclerosis: A comparison between human and experimental lesions.
Int Rev Exp Pathol7:
271–304,
1969.
24.
OlsenS.:
Pathology of renal allograft rejection.
In:
Kidney Disease, Present Status,
ed. ChurgJ.,
pp. 327–355.
Williams & Wilkins,
Baltimore,
1979.
25.
OlsenS.BohmanS.O.PetersenU.:
Ultrastructure of glomerular basement membrane in long term renal allografts with transplant glomerular disease.
Lab Invest30:
176–189,
1974.
26.
RyanG.B.KarnovskyM.J.:
Distribution of endogenous albumin in the rat glomerulus: Role of haemodynamic factors in glomerular barrier function.
Kidney Int9:
36–45,
1976.
27.
SeilerM.W.HoyerJ.R.KruegerT.E.:
Altered localization of protamine heparin complexes in aminonucleoside nephrosis.
Lab Invest43:
9–17,
1980.
28.
SpargoB.H.:
Pathologic lesions producing the nephrotic syndrome.
In:
Kidney Disease. Present Status,
ed. ChurgJ.,
pp. 56–75.
Williams & Wilkins,
Baltimore,
1979.
29.
SuzukiY.ChurgJ.GrishmanE.:
The mesangium of the renal glomerulus: Electron microscopic studies of pathologic alterations.
Am J Pathol43:
555–578,
1963.
30.
TabasLKornfeldS.:
Purification and characterization of a rat liver golgi α-mannosidase capable of processing asparagine-linked oligosaccharides.
J Biol Chem245:
11655–11663,
1979.
31.
WalkerF.:
The origin, turnover and renewal of glomerular basement membrane.
J Pathol110:
233–244,
1973.
