The ultrastructural features of a spontaneous malignant fibrous histiocytoma and three malignant histiocytomas in Sprague-Dawley rats are described. The ultrastructural features of the malignant histiocytomas (or histiocytic sarcomas) support origin from cells of the monocyte series. The histogenesis of more fibrous tumors (fibrous histiocytomas) remains uncertain.
CarstensP.B.H.SchrodtG.R.:
Ultrastructure of a sclerosing hemangioma.
Am J Pathol77:
377–382,
1974.
3.
CarterR. L.:
Tumours of soft tissues. In:
Pathology of Tumours in Laboratory Animals,
vol. 1,
Tumours of the Rat,
ed. TurusovV. S.,
Part 1,
p. 157.
International Agency for Research on Cancer, Lyon,
1973.
4.
DamjanovI.SundermanF.W.Jr.MitchellJ.M.AllpassP.R.:
Induction of testicular sarcomas in Fischer rats by intratesticular injection of nickel subsulfide.
Cancer Res38:
268–276,
1978.
5.
FuY.S.GabbianiG.KayeG.I.LattesR.:
Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies.
Cancer35:
176–198,
1975.
6.
GoodmanD.G.WardJ.M.SquireR.A.PaxtonM.B.ReichardtW.D.ChuK.C.LinhartM.S.:
Neoplastic and non-neoplastic lesions in aging Osborne-Mendel rats.
Toxicol Appl Pharmacol55:
433–447,
1980.
HarrisM.:
The ultrastructure of benign and malignant fibrous histiocytomas.
Histopathology4:
29–44,
1980.
9.
JohnsonW.W.CoburnT.P.PrattC.B.SmithJ.W.Mahesh KumarA.P.DahlinD.C.:
Ultrastructure of malignant histiocytoma arising in the acromion.
Hum Pathol9:
199–209,
1978.
10.
KatenkampD.StillerD.:
Cellular composition of the so-called dermatofibroma (histiocytoma cutis).
Virchows Arch [Pathol Anat]367:
325–336,
1975.
11.
KatenkampD.StillerD.:
Structural patterns and histological behavior of experimental sarcomas. II. Ultrastructural cytology.
Exp Path11:
190–206,
1975.
12.
KaufmanS.L.StoutA.P.:
Histiocytic tumors (fibrous xanthoma and histiocytoma) in children.
Cancer14:
469–482,
1961.
OzzelloL.HamelsJ.:
The histiocytic nature of dermato-fibrosarcoma protuberans. Tissue culture and electron microscopic study.
Am J Clin Pathol65:
136–148,
1976.
16.
OzzelloL.StoutA.P.MurrayM.R.:
Cultural characteristics of malignant histiocytomas and fibrous xanthomas.
Cancer16:
331–344,
1963.
17.
PapadimitriouJ.M.ArcherM.:
The morphology of murine foreign body multinucleate giant cells.
U Ultrastruct Res49:
372–386,
1974.
18.
PradhanS.N.ChungE.B.GhoshB.PaulB.D.KapadiaG.J.:
Potential carcinogens. I. Carcinogenicity of some plant extracts and their tannin-containing fractions in rats.
JNCI52:
1579–1582,
1974.
19.
SouleE.H.EnriquezP.:
Atypical fibrous histiocytoma, malignant fibrous histiocytoma, malignant histiocytoma and epithelioid sarcoma. A comparative study of 65 tumors.
Cancer30:
128–143,
1972.
20.
SquireR.A.BrinkhousK.M.PeiperS.C.FirmingerH.I.MannR.B.StrandbergJ.D.:
Histiocytic sarcoma with a granuloma-like component occurring in a large colony of Sprague-Dawley rats.
Am J Pathol105:
21–30,
1981.
21.
SuttonJ.S.WeissL.:
Transformation of monocytes in tissue culture into macrophages, epithelioid cells and multinucleate giant cells.
J Cell Biol28:
303–332,
1966.
22.
TaxyJ.B.BattiforaH.:
Malignant fibrous histiocytoma, an electron microscopic study.
Cancer40:
254–267,
1977.
23.
WardJ.M.KulwichB.A.ReznikG.BermanJ.J.:
Malignant fibrous histiocytoma. An unusual neoplasm of soft tissue origin in the rat that is different from the human counterpart.
Arch Pathol Lab Med105:
313–316,
1981.
24.
WeissS.W.EnzingerF.M.:
Malignant fibrous histiocytoma. An analysis of 200 cases.
Cancer41:
2250–2266,
1978.