In a longevity study on 320 male and 320 female specified-pathogen-free Han: Wistar rats, 119 (39.0%) of 305 females evaluated developed spontaneous metastatic uterine adenocarcinomas. These tumors caused a great difference between the mortality rates of males and females.
Thirty five percent of the females died of adenocarcinomas of the uterus. The tumors began as small nodules in one or both horns near the bifurcation. Large tumors extended through the uterine wall and produced wide-spread transcoelomic metastases. Early lesions were well-differentiated adenocarcinomas but advanced tumors were more poorly differentiated.
References
1.
BabaN.von HaamE.:
Experimental carcinoma of the endometrium.
Prog Exp Tumor Res9:
192–260,
1967.
2.
BabaN.von HaamE.:
Tumours of the vagina, uterus, placenta and oviduct.
In:
Pathology of Tumours in Laboratory Animals,
ed. Turusov,
Vol. I,
pp. 161–188.
Tumours of the rat (Part 2). IARC Scientific Publications No. 6, Lyon,
1976.
3.
BullockB.C.BanksK.L.ManningP.J.:
Common lesions in the aged rat.
In:
The Laboratory Animal in Gerontological Research,
pp. 62–82.
Natl Acad Sci Publication 1591, Washington D.C.,
1968.
4.
BullockF.D.CurtisM.R.:
Spontaneous tumours of the rat.
J Cancer Res14:
1–115,
1930.
5.
BurekJ.D.:
Pathology of Aging Rats.
CRC Press, Inc.,
Palm Beach, Fla.,
1978.
6.
DeerbergF.PittermannW.RappK.:
Longevity study in Han:Wistar rats: Experience in maintaining aging rats for gerontological investigations.
Interdiscipl Top Gerontol13:
66–74,
1978.
7.
FranksL.M.:
Normal and pathological anatomy and histology of the genital tract of rats and mice.
In:
Pathology of Laboratory Rats and Mice,
ed. CotchinRoe,
pp. 469–496.
Blackwell Scientific Publications,
Oxford and Edinburgh,
1967.
8.
GellatlyJ.B.M.:
In:
Pathology of Laboratory Rats and Mice,
ed. CotchinRoe,
p. 499.
Blackwell Scientific Publications,
Oxford and Edinburgh,
1967.
9.
GoodmanD.G.WardJ.M.SquireR.A.ChuK.C.LinhartM.:
Neoplastic and nonneoplastic lesions in aging F 344 rats.
Toxicol Appl Pharmacol48:
237–248,
1978.
10.
GrahamW.R.:
Recovery of a pleuropneumonia-like organism (PPLO) from the genitalia of the female albino rat.
Lab Anim Care13:
719–724,
1963.
11.
GuerinM.:
Tumeurs spontanés des animaux de laboratoire,
pp. 33–37,
103–112,
116.
Legrand,
Paris,
1954.
12.
RehmS.DeerbergF.RappK.:
Lifespan and characteristic diseases in mated and unmated rats of the Han:Wistar stock.
Zwierzeta Laboratoryzne17:
91–96,
1980.
13.
SassB.RabsteinL.S.MadisonR.NimsR.M.PetersR.L.KelloffG.J.:
Incidence of spontaneous neoplasms in F 344 rats throughout the natural life-span.
J Natl Cancer Inst54:
1449–1456,
1975.
14.
SchulzeE.:
Spontantumoren der Schädelhöhle und Genitalorgane bei Sprague-Dawley und Bethesda-black-Ratten.
Z Krebsforsch64:
78–82,
1960.
15.
SnellK.C.:
Spontaneous lesions of the rat.
In:
The Pathology of Laboratory Animals,
ed. RibelinMcCoy,
pp. 241–302.
Charles Thomas,
Springfield, Ill.,
1965.
16.
ThunertA.:
Escherichia coli in laboratory animals.
Z Versuchstierkd20:
19–27,
1978.
