A tumor of the left testicle resembling a gonadoblastoma was an incidental finding at necropsy in a 15-year-old male Shetland Sheepdog. This neoplasm was characterized by discrete intratubular aggregates of intimately mixed germ cells and smaller cells resembling Sertoli cells. The latter small cells often formed a single cell layer surrounding the margin of eosinophilic, PAS-positive Call-Exner-like bodies. Electron microscopy showed these bodies to be composed of whorled laminae resembling basement membrane.
References
1.
von BomhardD.PukkavesaC.HaenichenT.:
The ultrastructure of testicular tumors in the dog: I. Germinal cells and seminomas.J Comp Pathol88:
49–57,
1978
2.
von BomhardD.PukkavesaC.HaenichenT.:
The ultrastructure of testicular tumors in the dog: III. Sertoli cells and Sertoli cell tumors and general conclusions.J Comp Pathol88:
67–73,
1978
3.
CotchinE.:
Testicular neoplasms in dogs.J Comp Pathol70:
232–248,
1960
4.
GreenblattR.B.ByrdJ.R.McDonoughP.G.MaheshV.B.:
The spectrum of gonadal dysgenesis—A clinical, cytogenetic, and pathologic study.Am J Obstet Gynecol98:
151–172,
1967
5.
HauserB.WildP.:
Two unusual Sertoli cell tumors in dogs.J Comp Pathol88:
327–333,
1978
6.
HayesH.M.PendergrasT.W.:
Canine testicular tumors: Epidemiologic features of 410 dogs.Int J Cancer18:
482–487,
1976
7.
HughesdonP.E.KumarasamyT.:
Mixed germ cell tumors (gonadoblastomas) in normal and dysgenetic gonads.Virchows Arch [Pathol Anat]349:
258–280,
1970
8.
McCauleyM.A.WelikyI.SchulzR.A.:
Ultrastructure of a biosynthetically active granulosa cell tumor.Lab Invest17:
562–570,
1967
9.
MacKayA.M.PettigrewM.B.SymingtonT.NevilleA.M.:
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects.Cancer34:
1108–1125,
1974
10.
MustofiF.K.SobinL.H.:
Histological Typing of Testis Tumors,
pp. 33–34.
World Health Organization,
Geneva,
1977
11.
RobertsS.J.:
Veterinary Obstetrics and Genital Diseases (Theriogenology),
pp. 613,
633,
692.
Edwards Brothers, Inc.,
Ann Arbor,
1971
12.
Ibid,
pp. 472,
542
13.
ScullyR.E.:
Gonadoblastoma. A gonadal tumor related to dysgerminoma (seminoma) and capable of sex hormone production.Cancer6:
445–463,
1953
14.
ScullyR.E.:
Gonadoblastoma. A review of 74 cases.Cancer25:
1340–1356,
1970
15.
SerovS.F.ScullyR.E.SobinL.H.:
Histological Typing of Ovarian Tumors,
pp. 42–43,
50.
World Health Organization,
Geneva,
1973
