Abstract
A lysosomal storage disease with accumulation of periodic acid-Schiff- and Sudan black-positive autofluorescent granules in neurons occurred in one 51/2- and one 7-year-old dachshund. Ultrastructurally, the storage material consisted of membranous material arranged in stacks and fingerprint patterns. The disease was defined as ceroid-lipofuscinosis, and resembled a previously reported case in an adult dachshund.
References
1.
Crome
L.
Stern
J.
:
Inborn lysosomal enzyme deficiencies .
In :
Greenfield's Neuropathology ,
ed.
Blackwood
Corsellis
,
pp. 531 –534 ,
3rd ed.
Edward Arnold ,
London ,
1976 .
2.
Cummings
J.F.
de Lahunta
A.
:
An adult case of canine neuronal ceroid-lipofuscinosis .
Acta Neuropathol (Berl
39 :
43 –51 ,
1977 .
3.
Fankhauser
R.
:
Altersbedingte Veränderungen am Zentralnervensystem bei Hund und Katze .
Berl Münch Tierärztl Wochenschr
85 :
47 –50 ,
1972 .
4.
Fankhauser
R.
:
Zentrales und peripheres Nervensystem .
In :
Klinik der Hundekrankheiten ,
ed.
Christoph
,
p. 616 .
Gustav Fischer Verlag ,
Stuttgart ,
1973 .
5.
Green
P.D.
Little
P.B.
:
Neuronal ceroid-lipofuscin storage in Siamese cats .
Can J Comp Med
38 :
207 –212 ,
1974 .
6.
Jolly
R.D.
Blakemore
W.F.
:
Inherited lysosomal storage diseases: An essay in comparative medicine .
Vet Rec
92 :
391 –400 ,
1973 .
7.
Jolly
R.D.
Hartley
W.J.
:
Storage diseases of domestic animals .
Aust Vet J
53 :
1 –8 ,
1977 .
8.
Karbe
E.
:
Amaurotische Idiotie bei Hund und Mensch .
Bull Schweiz Akad Med Wiss
24 :
95 –105 ,
1968 .
9.
Koppang
N.
:
Neuronal ceroid-lipofuscinosis in English setters .
J Small Anim Pract
10 :
639 –644 ,
1970 .
10.
Koppang
N.
:
Canine ceroid-lipofuscinosis—A model for human neuronal ceroid-lipofuscinosis and aging .
Mech Ageing Dev
2 :
421 –445 ,
1973 .
11.
Krinke
G.
Pericin
C.
Thomann
P.
Hess
R.
:
Toxic encephalopathy with hippocampal lesions .
Zentralbl Veterinaermed [A]
25 :
277 –296 ,
1978 .
12.
Lindsey
J.R.
Capen
C.C.
:
Animal models for biomedical research VI—Metabolic disease .
Fed Proc
5 :
1192 ,
1976 .
13.
Peters
A.
Palay
S.L.
Webster
H.deF.
:
The fine structure of the nervous system ,
pp. 36 –37 .
W.B. Saunders Company ,
Philadelphia, London, Toronto ,
1976 .
14.
Rac
R.
Giesecke
P.R.
:
Lysosomal storage disease in Chihuahuas .
Aust Vet J
51 :
403 –404 ,
1975 .
15.
Wolfe
L.S.
Ng Ying Kin
N.M.K.
Baker
R.R.
Carpenter
S.
Andermann
F.
:
Identification of retinoyl complexes as the autofluorescent component of the neuronal storage material in Batten disease .
Science
195 :
1360 –1362 ,
1977 .