Twenty-eight guinea pigs from nine episodes of subclinical scurvy had diarrhea, weight loss and dehydration. The classical signs of scurvy were not seen. Microscopically the epiphyses were attenuated and irregular. The amount of osteoid was less than normal. Many guinea pigs had acute enteritis. In some there were many hemosiderin-laden macrophages in the intestinal lamina propria. All episodes were associated with either autoclaving food without adequate supplementation or other inadequate feed management practices.
References
1.
BonucciE.:
The fine structure of epiphyseal cartilage in experimental scurvy.J Pathol102:
219–227,
1970
2.
HoringD.WeiserH.:
Ascorbic acid and cholesterol: effect of graded oral intakes on cholesterol conversion to bile acids in guinea pigs.Experientia32:
687–689,
1976
3.
HuntC.E.:
Personal commun.,
1978
4.
JenkinsS.A.:
Hypovitaminosis C and cholelithiasis in guinea pigs.Biochem Biophys Res Commun77:
103–105,
1977
5.
NavaJ.M.HuntC.E.:
Nutrition, nutritional disease and nutritional research applicationinThe Biology of the Guinea Pig,
ed. WagnerManning
pp. 247–250;
Academic Press,
New York,
1976