A dog with a lymphoproliferative disease resembling mycosis fungoides in man, the second reported canine case, had slowly progressive, multicentric cutaneous nodules and plaques. Nearly half the body surface was involved. The lesions consisted of multiple, flat, infiltrative, cutaneous tumors composed of heterogeneous, pleomorphic cells, some of which resembled histiocytes or activated lymphocytes. Intracutaneous foci of tumor cells and numerous tumor cells with bizarre convoluted nuclei were distinctive features that permitted the lesions to be distinguished from other non-epithelial cutaneous neoplasms.
References
1.
BroderS.EdelsonR.L.LutznerM.A.NelsonD.L.MacDermottR.P.DurmM.E.GoldmanC.K.MeadeB.D.WaldmannT.A.:
The Sézary syndrome: a malignant proliferation of helper T cells.J Clin Invest58:
1297–1306, 1976
2.
BrownleeT.R.MuradT.M.:
Ultrastructure of mycosis fungoides.Cancer26:
686–698, 1970
3.
DrommerW.SchulzL.C.:
Vergleichende licht- und elektronenmikroskopische Untersuchungen am übertragbaren venerischen Sarkom und Histiozytom des Hundes.Pathol Vet6:
273–286, 1969
4.
EdelsonR.L.KirkpatrickC. H.ShevachE.M.ScheinP.S.SmithR.W.GreenI.LutznerM.:
Preferential cutaneous infiltration by neoplastic thymus-derived lymphocytes. Morphologic and functional studies.Ann Intern Med80:
685–692, 1974
5.
FlaxmanB.A.ZelaznyG.Van ScottE.J.:
Nonspecificity of characteristic cells in mycosis fungoides.Arch Dermatol104:
141–147, 1971
6.
GriemM.L.MoranE.M.FergusonD.J.MettlerF.A.GriemS.F.:
Staging procedures in mycosis fungoides.Br J Cancer31:
362–367, 1975
7.
HowardE.B.NielsenS.W.KenyonA.J.:
Cutaneous lymphomatosis in a Boxer dog. Pathologic and biochemical observations.Pathol Vet6:
76–85, 1969
8.
HowardE.B.NielsenS.W.:
Cutaneous histiocytomas of dogs.Natl Cancer Inst Mongr32:
321–327, 1969
9.
KellyD.F.:
Canine cutaneous histiocytoma: a light and electron microscopic study.Pathol Vet7:
12–27, 1970
10.
KellyD.F.HalliwallR.E.W.SchwartzmanR.M.:
Generalized cutaneous eruption in a dog, with histiological similarity to human mycosis fungoides.Br J Dermatol86:
164–171, 1972
11.
LeverW.F.Schaumburg-LeverG.:
Mycosis fungoidesInHistopathology of the Skin,
5th ed.,
pp. 696–705; Lippincott, Philadelphia, 1975
12.
LongJ.C.MihmM.C.:
Mycosis fungoides with extracutaneous dissemination: a distinct clinicopathologic entity.Cancer34:
1745–1755, 1974
13.
LutznerM.A.HobbsJ.W.HorvathP.:
Ultrastructure of abnormal cells in Sézary syndrome, mycosis fungoides, and parapsoriasis en plaque.Arch Dermatol103:
375–386, 1971
14.
LutznerM.EdelsonR.ScheinP.GreenI.KirkpatrickC.AhmedA.:
Cutaneous T-cell lymphomas: the Sézary syndrome, mycosis fungoides, and related disorders.Ann Intern Med83:
534–552, 1975
15.
Rosas-UribeA.VariakojisD.MolnarZ.RappaportH.:
Mycosis fungoides: an ultrastructural study.Cancer34:
634–645, 1974
16.
SandbankM.:
Mycosis fungoides. Ultrastructural study with demonstration of atypical cells and nuclear bodies.Arch Dermatol103:
206–214, 1971
