Histochemical and electron microscope studies indicated there was amyloid in corpora amylacea in tumors, duct ectasias and lobular hyperplasias of rat mammary glands. Electron microscopy showed fibrils that closely resembled amyloid fibrils in human and bovine amyloid and in bovine corpora amylacea. Amyloid deposition may be more common in rats than is generally thought.
References
1.
BoormanG.A.NoordM.J.vanHollanderC.F.:
Naturally occurring medullary thyroid carcinoma in the rat.
Arch Pathol94:
35–41,
1972.
2.
FranklinE.C.Zucker-FranklinD.:
Current concepts of amyloid.
Adv Immunol15:
249–304,
1972.
3.
GlennerG.G.PageD.L.:
Amyloid, amyloidosis and amyloidogenesis.
Int Rev Exp Pathol15:
1–92,
1976.
4.
GreenC.J.:
Amyloidosis as an incidental finding in rats on experiment.
Lab Anim8:
99–101,
1974.
5.
GruysE.:
Ultrastructural and enzyme histochemical aspects of amyloidosis in the bovine renal medulla.
Vet Pathol12:
94–110,
1975.
6.
HighmanB.:
Improved methods for demonstrating amyloid in paraffin sections.
Arch Pathol41:
559–563,
1946.
7.
PearseA.G.E.EwenS.W.B.PolakJ.M.:
The genesis of apudamyloid in endocrine polypeptide tumours: histochemical distinction from immunamyloid.
Virchows Arch [Zellpathol]10:
93–107,
1972.
8.
ReidI.M.:
Corpora amylacea of the bovine mammary gland. Histochemical and electron-microscopic evidence for their amyloid nature.
J Comp Pathol82:
409–413,
1972.
9.
RomhányiG.:
Selective differentiation between amyloid and connective tissue structures based on the collagen specific topo-optical staining reaction with congo red.
Virchows Arch [Pathol Anat]354:
209–222,
1971.
