Tyzzer's disease (bacillus piliformis infection) was diagnosed in a young guinea pig killed because of diarrhea and poor condition. There was necrosis and inflammation of the colon, cecum and ileum. Typical B. piliformis were in intestinal epithelial cells. Spirochetes were in large numbers in intestinal crypts and were often adjacent to the intracellular B. piliformis. Extracellular B. piliformis occasionally were surrounded by spirochetes.
CraigieJ.:
'Bacillus piliformis' (Tyzzer) and Tyzzer's disease of the laboratory mouse. I. Propagation of the organism in embryonated eggs.
Proc R Soc Lond (Biol)165:
35–60,
1966.
3.
DavisC.P.MulcahyD.TakeuchiA.SavageD.C.:
Location and description of spiral-shaped microorganisms in the normal rat cecum.
Infect Immun6:
184–192,
1972.
4.
FujiwaraK.KurashinaH.MatsunumaN.TakahashiR.:
Demonstration of peritrichous flagella of Tyzzer's disease organism.
Jpn J Microbiol12:
361–363,
1968.
5.
GanawayJ.R.AllenA.M.MooreT.D.:
Tyzzer's disease.
Am J Pathol64:
717–730,
1971.
6.
GotoN.OghisoY.LeeY.S.TakahashiR.FujiwaraK.:
Fine structure of the Tyzzer's organism in the feline liver.
Jpn J Exp Med44:
373–378,
1974.
7.
HallW.C.Van KruiningenH.J.:
Tyzzer's disease in a horse.
J Am Vet Med Assoc194:
1187–1189,
1974.
8.
JonasA.M.PercyD.H.CraftJ.:
Tyzzer's disease in the rat. Its possible relationship with megaloileitis.
Arch Pathol90:
516–528,
1970.
9.
KarstadL.LusisP.WrightD.:
Tyzzer's disease in muskrats.
J Wildl Dis7:
96–99,
1971.
10.
KovatchR.M.ZebarthB.:
Naturally occurring Tyzzer's disease in a cat.
J Am Vet Med Assoc162:
136–138,
1973.
11.
ListgartenM.A.SocranskyS.S.:
Electron microscopy of axial fibrils, outer envelope, and cell division of certain oral spirochetes.
J Bacteriol88:
1087–1103,
1964.
12.
NivenJ.S.F.:
Tyzzer's disease in laboratory animals.
Z Versuchstierkd10:
168–173,
1968.
13.
PeaseP.:
Some observations upon the development and mode of attachment of the flagella in Vibrio and Spirillum species.
Exp Cell Res10:
234–237,
1956.
14.
PulleyL.T.ShivelyJ.N.:
Tyzzer's disease in a foal. Light- and electron-microscopic observations.
Vet Pathol11:
203–211,
1974.
15.
RoseburyT.:
Microorganisms indigenous to man,
p. 132,
321;
McGraw-Hill,
New York,
1962.
16.
SavageD.C.McAllisterJ.S.DavisC.P.:
Anaerobic bacteria on the mucosal epithelium of the murine large bowel.
Infect Immun4:
492–502,
1971.
17.
TakeuchiA.JervisH.R.NakazawaH.RobinsonD.M.:
Spiral-shaped organisms on the surface colonic epithelium of the monkey and man.
Am J Clin Nutr27:
1287–1296,
1974.
18.
TakeuchiA.ZellerJ.A.:
Scanning electron microscopic observations on the surface of the normal and spirochete-infested colonic mucosa of the Rhesus monkey.
J Ultrastruct Res40:
313–324,
1972.
19.
TyzzerE.E.:
A fatal disease of the Japanese waltzing mouse caused by a spore-bearing bacillus (Bacillus piliformis, n.sp.).
J Med Res37:
307–338,
1917.
20.
WhiteD.J.WaldronM.M.:
Naturally occurring Tyzzer's disease in the gerbil.
Vet Rec85:
111–114,
1969.
