The intimal surface of the aortic arch of 16 of 20 male common brown hares and 10 of 14 females had raised pale yellow to grey-white plaques up to 6 mm in diameter. These lesions were characterised by necrosis and calcification mainly in the tunica media and were not related to the age of the hares. In the hare this vascular disease may develop after injury to the connective tissue during obliteration of the ductus arteriosus. Although these aortic lesions were not the ‘spontaneous’ atherosclerotic variety they were morphologically similar to those in rabbits.
References
1.
BlumenthalH. T.LansingA. I.GrayS. H.:
The interrelation of elastic and calcium in the genesis of arteriosclerosis.Am. J. Path.26:
989–1009(1950)
2.
CaroC. G.Fitz-GeraldJ. M.SchroterR. C.:
Arterial wall shear and distribution of early atheroma in man.Nature, Lond.223:
1159–1161(1969)
3.
DuffG. L.:
Experimental cholesterol arteriosclerosis and its relationship to human arteriosclerosis.Archs Path.20:
81–123,
259–304(1935)
4.
FinlaysonR.:
Spontaneous arterial disease in exotic animals.J. Zool.147:
239–343(1965)
5.
GillmanT.HathornM.:
Pathogenesis of arterial sclerosis in the light of modern views on vascular microanatomy and the role of polysaccharides in wound healing.J. Mt Sinai Hosp.24:
857–868(1957)
6.
HaustD. M.MoreR. H.:
Spontaneous lesions of the aorta in the rabbit; in
Roberts, Straus and Cooper Comparative atherosclerosis,
pp. 255–275
(Harper & Row,
New York1965)
7.
HudsonR. E. B. (ed.):
Atheroma lesions and their grading,
pp. 303–326;
Marfan's syndrome, pp. 521–527; Buerger's disease, Takiyashu's disease, pp. 531–538; in
Cardiovascular pathology
(Edward Arnold,
London1965)
8.
IsraelO.:
Experimentelle Untersuchung über den Zusammenhang zwischen Nierenkrankheiten und secundären Veränderungen des Circulationssystems.Virchows Arch. path. Anat. Physiol.86:
299–321(1881)
9.
MönckebergJ. G.:
Über die reine Mediaverkalkung der Extremitätenarterien und ihr Verhalten zur Arteriosklerose.Virchows Arch. path. Anat. Physiol.171:
141–167(1903)
10.
RobertsJ. C.StrausR.CooperM. S.:
Comparative atherosclerosis
(Harper & Row,
New York1965)
11.
WrightL. J.:
Widespread spontaneous aortic lesions in the common brown hare (Lepus europaeus).Atherosclerosis17:
151–155(1973)
12.
ZeekP. M.:
Familial factors in arterosclerosis in rabbits.Archs Path.16:
302(1933)