Two separate episodes of an encephalitis occurred in dogs after the administration of a few batches of a combined, live attenuated distemper/hepatitis virus vaccine. The lesions consisted of eosinophilic intranuclear and intracytoplasmic inclusions in large neurones, together with a nonsuppurative encephalitis and malacia of the ventral pontine gray matter. The presence of nucleocapsid, indistinguishable from that seen in distemper infection, indicates that a distemper or distemper-like virus was directly involved.
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