A juvenile Rhesus monkey died suddenly while being conditioned for tissue culture studies. A diagnosis of necrotizing pancreatitis associated with adenovirus was made on the basis of the demonstration by electron microscopy of paracrystalline arrays of viral particles and granular and fibrillar inclusions in necrotic pancreatic acinar cells. This is the first description of necrotizing pancreatitis in a nonhuman primate. Adenovirus should be considered in the etiology of pancreatitis in nonhuman primates.
References
1.
CraigheadJ. E.:
Viral induced pancreatic lesions and diabetes mellitus in man and animals.
Progr. med. Virol.,
vol. 16,
pp. 1–50
(Karger,
Basel1974).
2.
ErlandsonR. A.:
A new Maraglas, D. E. R.(R)732, embedment for electron microscopy.
J. Cell Biol.22:
704–709
(1964).
3.
GallinaA. M.WinterfieldR. W.FadlyA. M.:
Adenovirus infection and disease. II. Histopathology of natural and experimental disease.
Avian Dis.17:
343–353
(1973).
JubbK. V. F.KennedyP. C.:
Pathology of domestic animals;
2nd ed.,
vol. 2,
p. 264
(Academic Press,
New York1970).
6.
KimC. S.SueltenfussE. A.KalterS. S.:
Isolation and characterization of simian adenoviruses isolated in association with an outbreak of pneumoenteritis in vervet monkeys (Cercopithecus aethiops)..
J. infect. Dis.117:
292–300
(1967).
7.
LynnJ. A.MartinJ. H.RaceG. J.:
Recent improvements of histologic techniques for the combined light and electron microscopic examination of surgical specimens.
Amer. J. clin. Path.45:
704–713
(1966).
8.
Martinez-PalomoA.Le BuisJ.BernhardW.:
Electron microscopy of adenovirus 12 replication. I. Fine structural changes in the nucleus of infected KB cells.
J. Virol.1:
817–829
(1967).
9.
McChesneyA. E.EnglandJ. J.AddockJ. L.StackhouseL. L.ChowT. L.:
Adenoviral infection in suckling arabian foals.
Path. vet.7:
547–564
(1970).
10.
MorganC.RosenkranzH. S.MedaisB.:
Structure and development of viruses as observed in the electron microscope. X. Entry and uncoating of adenovirus.
J. Virol.4:
777–796
(1969).
11.
PapadimitriouJ. M.WaltersM. N. I.:
Studies on the exocrine pancreas. II. Ultrastructural investigation of reovirus pancreatitis.
Amer. J. Path.51:
387–403
(1967).
12.
PilleE. R.YermakovaY. Y.ZuyevaY. N.NadaichikL. V.:
Study of viruses isolated from monkeys.
Probl. Virol.6:
704
(1961).
13.
PinkertonH.CarrollS.:
Fatal adenovirus pneumonia in infants: correlation of histologic and electron microscopic observations.
Amer. J. Path.65:
543–546
(1971).
14.
VenableJ. H.CoggeshallR.:
A simplified lead citrate stain for use in electron microscopy.
J. Cell Biol.25:
407–413
(1965).
