Neoplastic reticulosis of the central nervous system was associated with intracytoplasmic inclusion bodies in Purkinje cells and neurons of several nuclei. These eosinophilic inclusion bodies were from round to crescentic and had a different location, structure, and cytochemistry than Negri bodies and inclusions of other canine neurologic diseases. The inclusions represent an aberration of rough endoplasmic reticulum and resemble the cytoplasmic laminar bodies of the lateral geniculate neurons of the cat.
References
1.
CordyD. R.:
Canine encephalomyelitis.
Cornell Vet.32:
11–28
(1942).
2.
DoolinP. F.BarronK. D.KwakS.:
Ultrastructural and histochemical analysis of cytoplasmic laminar bodies in lateral geniculate neurons of adult cat.
Amer. J. Anat.121:
601–622
(1967).
3.
FankhauserR.FatzerR.LuginbuhlH.McGrathJ. T.:
Reticulosis of the central nervous system (CNS) in dogs; in
Advances in veterinary science and comparative medicine,
vol. 16,
pp. 35–71
(Academic Press,
New York1972).
4.
JubbK. V. F.KennedyP. C.:
Pathology of domestic animals;
2nd ed.,
vol. 2,
pp. 414–416
(Academic Press,
New York1970).
5.
LennetteE. H.EmmonsR. W.:
The laboratory diagnosis of rabies: review and prospective; in
Nagano and Davenport Rabies,
pp. 77–90
(Univ. of Tokyo Press,
Tokyo1971).
6.
LevaditiC.LépineP.:
Les ultravirus des maladies humaines,
p. 1599
(Librairie Malaine,
Paris1948).
7.
LincolnS. D.GorhamJ. R.OttR. L.HegrebergG. A.:
Etiologic studies of old dog encephalitis. xI. Demonstration of canine distemper viral antigen in the brain in two cases.
Vet. Path.8:
1–8
(1971).
8.
LunaL. G.:
Manual of histologic staining methods of the Armed Forces Institute of Pathology;
3rd ed.,
pp. 37,
87,
94,
121,
131,
145,
159,
161,
199,
203,
208,
220,
234,
(Blakiston, McGraw-Hill,
New York1968).
9.
MickwitzC.-U. von:
Einschlusskörperchen in den Ganglienzellen des Ammonshornes und des Thalamus von Haus- und Zookatzen.
Path. vet.3:
569–587
(1966).
10.
MiyamotoK.MatsumotoS.:
The nature of the Negri body.
J. Cell Biol.27:
677–6821965).
11.
MoralesR.DuncanD.RehmetR.:
A distinctive laminated cytoplasmic body in the lateral geniculate neurons of the cat.
J. Ultrastruct. Res.10:
116–123
(1964).
12.
SchochetS. S.jr.:
Neuronal inclusions; in
Bourne The structure and function of nervous tissue,
vol. 4,
pp. 129–177
(Academic Press,
New York1972).
13.
SmithH. A.JonesT. C.HuntR. D.:
Veterinary pathology;
4th ed.,
pp. 351 to
356
(Lea & Febiger,
Philadelphia1972).
14.
SzlochtaH. L.HabelR. E.:
Inclusions resembling Negri bodies in the brains of nonrabid cats.
Cornell Vet.43:
207–212
(1953).
15.
ThompsonS. W.:
Selected histochemical and histopathological methods;
1st ed.,
pp. 199,
266,
473
(Thomas,
Springfield1966).
