Smears from the genital epithelium of five dogs with mammary carcinoma contained cells that morphologically resembled those in tissue sections of the primary lesion. During postmortem examination of three of these animals cells exfoliated from selected sites were examined to identify the probable area of desquamation of tumor cells. Histologic sections of the grossly normal vestibules contained submucosal micrometastatic foci of tumor.
References
1.
BellE. T.ChristieD. W.YounglaiE. V.:
Plasma oestrogen levels during the oestrous cycle.
J. Endocrin.51:
225–226
(1971).
2.
BrodeyR. S.RoszelJ. F.:
Neoplasms of the canine uterus, vagina and vulva.
J. amer. vet. med. Ass.151:
1294–1307
(1967).
3.
CotchinE.:
Some tumors of dogs and cats of comparative veterinary and human interest.
Vet. Rec.71:
1040–1050
(1959).
4.
CotchinE.:
Spontaneous uterine cancer in animals.
Brit. J. Cancer18:
209-227
(1964).
DifferdingJ. T.:
Psammoma bodies in a vaginal smear.
Acta cytol.11:
199–201
(1967).
7.
EvansH. M.ColeH. H.:
An introduction to the oestrus cycle in the dog
(University of California Press,
Berkeley1931).
8.
FowlerE. H.LoebW. F.WilsonG. P.III:
Vaginal cytologic examination of intact and ovariohysterectomized bitches with mammary neoplasia.
Amer. J. vet. Res.31:
51–59
(1970).
9.
FowlerE. W.FeldmanM. K.LoebW. F.:
Comparison of histologic features of ovarian and uterine tissues with vaginal smears of the bitch.
Amer. J. vet. Res.32:
327–334
(1971).
10.
GarrettR.:
Extrauterine tumor cells in vaginal and cervical smears.
Obstet. Gynec., N. Y.14:
21–27
(1959).
11.
GierH. T.:
Estrous cycle in the bitch: vaginal fluids.
Vet. Scope5:
2–9
(1960).
12.
GrahamR. M.NickerW. A. van:
Vaginal cytology in cancer of the ovary.
Acta cytol.6:
496–499
(1962).
13.
HooperB. E.HallA.DaleH. E.:
Characteristics of the vaginal smear in the bitch.
Small anim. Clin.1:
355–359
(1961).
14.
KossL. G.:
Diagnostic cytology and its histopathologic bases;
1st ed.,
p. 154-157
(Lippincott,
Philadelphia1961).
15.
LuibelF. J.SandersE.AshworthC. T.:
An electron microscopic study of carcinoma in situ and invasive carcinoma of the cervix uteri.
Cancer Res.20:
357–361
(1960).
16.
RoszelJ. F.:
Exfoliative cytology in diagnosis of malignant canine neoplasms.
Vet. Scope12:
14–19
(1960).
17.
RoszelJ. F.:
Genital cytology of the bitch.
Vet. Scope20:
(in press,
1975).
18.
SchutteA. P.:
Canine vaginal cytology. I. Technique and cytological morphology.
J. small anim. Prac.8:
301–306
(1967).
19.
SchutteA. P.:
Canine vaginal cytology. II. Cyclic changes.
J. small anim. Prac.8:
307–311
(1967).
20.
SchutteA. P.:
Canine vaginal cytology. III. Compilation and evaluation of cellular indices.
J. small anim. Prac.8:
313–317
(1967).
21.
SongY. S.:
The significance of positive vaginal smears in extrauterine carcinomas.
Amer. J. Obstet. Gynec.73:
341–348
(1957).
22.
WitiakE.:
The use of vaginal smears to determine ovulation in the bitch.
Vet. Med.62:
869–878
(1967).