Abstract
Five-day-old germ-free piglets were challenged intranasally with Bordetella bronchiseptica. Infection with this agent consistently resulted in an acute bronchopneumonia characterized by broncholitis, hemorrhage, edema, necrosis, and epithelialization. In the absence of predisposing factors such as the additive or synergistic activity of a virus or mycoplasma, it was concluded that strains of B. bronchiseptica can initiate respiratory tract infections and in susceptible young swine can be a primary cause of pneumonia.
References
1.
Winsser
J.
:
A study of Bordetella bronchiseptica.
.
Proc. anim. Care Panel
10 :
87 –104
(1960 ).
2.
Woode
G. N.
McLeod
N.
:
Control of acute Bordetella bronchiseptica pneumonia in a guinea pig colony .
Lab. Anim.
1 :
91 –94
(1967 ).
3.
Smith
D. T.
Webster
L. T.
:
Epidemiological studies on respiratory infections of the rabbit. VI. Etiology of otitis media .
J. exp. Med.
41 :
275 –283
(1925 ).
4.
Graves
I. L.
:
Bordetella bronchiseptica isolates from a fatal case of bronchopneumonia in an African green monkey .
Lab. anim. Care
18 :
405 –406
(1968 ).
5.
Snyder
S. B.
Fisk
S. K.
Soave
O. A.
:
Respiratory tract disease associated with Bordetella bronchiseptica infection in cats .
J. amer. vet. med. Ass.
163 :
293 –294
(1973 ).
6.
Bruner
D. W.
Gillespie
J. H.
:
Hagen's infectious diseases of domestic animals ;
6th ed. ,
p. 195
(Cornell Univ. Press ,
Ithaca
1973 ).
7.
Torrey
J. C.
Rahe
A. H.
:
Studies in canine distemper .
J. med. Res.
27 :
291 –364
(1913 ).
8.
Phillips
C. E.
:
Alcaligenes (Brucella) bronchiseptica as a factor in porcine pneumonias .
Canad. J. comp. Med. vet. Sci.
7 :
58 –59
(1943 ).
9.
Dunne
H. W.
Kradel
D. C.
Doty
R. B.
:
Bordetella bronchiseptica (Brucella bronchiseptica) in pneumonia in young pigs .
J. amer. vet. med. Ass.
139 :
897 –899
(1961 ).
10.
Ray
J. D.
:
Bordetella bronchiseptica.
J. amer. vet. med. Ass.
116 :
51
(1950 ).
11.
Cross
R. F.
Claflin
R. M.
:
Bordetella bronchiseptica -induced porcine atrophic rhinitis .
J. amer. vet. med. Ass.
141 :
1467 –1468
(1962 ).
12.
Ross
R. F.
Duncan
J. R.
Switzer
W. P.
:
Turbinate atrophy in swine produced by pure cultures of Bord bronchiseptica.
.
Vet. Med.
58 :
566 –570
(1963 ).
13.
Ross
R. F.
Switzer
W. P.
Mare
C. J.
:
Incidence of certain microorganisms in Iowa swine .
Vet. Med.
58 :
562 –565
(1963 ).
14.
Meyer
R. C.
Bohl
E. H.
Kohler
E. M.
:
Procurement and maintenance of germ-free swine for microbiological investigations .
Appl. Microbiol.
12 :
295 –300
(1964 ).
15.
Luna
L. G.
:
Manual of histologic staining methods of the Armed Forces Institute of Pathology ;
3rd ed. ,
p. 34
(McGraw-Hill ,
New York
1968 ).
16.
Meyer
R. C.
Saxena
S. P.
Rhoades
H. E.
:
Polyserositis induced by Escherichia coli in gnotobiotic swine .
Infect. Immun.
3 :
41 –44
(1971 ).
17.
Duncan
J. R.
Ramsey
F. K.
Switzer
W. P.
:
Pathology of experimental Bordetella bronchiseptica infection in swine: pneumonia .
Amer. J. vet. Res.
27 :
467 –472
(1966 ).
18.
Seibold
H. R.
Perrin
E. A.
jr.
Garner
A. C.
:
Pneumonia associated with Bordetella bronchiseptica in callicebus species primates .
Lab. anim. Care
20 :
456 –461
(1970 ).
19.
Anderson
W. A. D.
:
Pathology ;
6th ed. ,
vol. 1 ,
p. 320
(Mosby ,
St. Louis
1971 ).