Abstract
Bilateral adrenocortical hyperplasia was present in 24 of 27 dogs with hyperadrenocorticalism. Two dogs had a unilateral adenoma, and one had a carcinoma of the adrenal cortex.
Bilateral cortical hyperplasia was diffuse or nodular. The difference between the two patterns of hyperplasia was not associated with any consistent varation in the clinical or endocrinologic features. In the three dogs with adrenal cortical neoplasia there was marked cortical atrophy of the contralateral adrenal gland. Extracapsular nodular hyperplasia was common in the adrenals of dogs with hyperadrenocorticalism and also in older control dogs without endocrine disease. Ten of the dogs with bilateral adrenocortical hyperplasia were examined postmortem; two had a chromophobe adenoma of the pituitary, but no pituitary lesion was found in the others.