Twenty-two goats were poisoned with daily oral doses of ground coyotillo fruits and were killed at various times after the first day of dosing. The morphologic features and distribution of lesions in the central nervous system were studied by light microscopy.
An axonal dystrophy occurred in several of the goats given high daily doses. Swellings occurred along axons of Purkinje cells in the cerebellum and in the white matter of the spinal cord. There was a fairly close correlation between the occurrence of clinical signs suggestive of the neocerebellar syndrome and the occurrence and distribution of lesions in the cerebellum.
BrodalA.:
Neurological Anatomy
(Oxford University Press,
New York1969)
3.
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Buckthorn polyneuropathy.New Engl. J. Med.277:
69–71
(1967)
4.
CharltonK.M.ClabornL.D.PierceK.R.:
A neuropathy in goats caused by experimental coyotillo (Karwinskia bumboldtiana) poisoning. I. Clinical and neurophysiologic studies.
(Submitted to Amer. J. vet. Res.,
1970)
5.
CharltonK.M.PierceK.R.:
Peripheral neuropathy in experimental coyotillo poisoning in goats.Texas Rep. Biol. Med.27:
389–399
(1969)
6.
CharltonK.M.PierceK.R.:
A neuropathy in goats caused by experimental coyotillo (Karwinskia humboldtiana) poisoning. II. Lesions in the peripheral nervous system—Teased fiber and acid phosphatase studies.Path. Vet.7:
385–407
(1970)
7.
CharltonK.M.PierceK.R.:
A neuropathy in goats caused by experimental coyotillo (Karwinskia humboldtiana) poisoning. III. Distribution of lesions in peripheral nerves.Path. Vet.7:
408–419
(1970)
8.
ChouS-M.HartmannH.A.:
Axonal lesions and waltzing syndrome after IDPN administration in rats.Acta Neuropath.3:
428–450
(1964)
9.
CordyD.R.RichardsW. P. C.BradfordG.E.:
Systemic neuroaxonal dystrophy in Suffolk sheep.Acta Neuropath.8:
133–140
(1967)
10.
DewanM.L.HensonJ.B.DollahiteJ.W.BridgesC.H.:
Toxic myodegeneration in goats produced by feeding mature fruits from the coyotillo plant (Karwinskia humboldtiana).Amer. J. Path.46:
215–226
(1965)
11.
DunnH.C.DolmanC.L.:
Necrotizing encephalomyopathy. Report of a case with relapsing polyneuropathy and hyperalaninemia and with manifestations resembling Friedreich's ataxia.Neurology19:
536–550
(1969)
12.
Hedley-WhyteE.T.GillesF.H.UzmanB.G.:
Infantile neuroaxonal dystrophy. A disease characterized by altered terminal axons and synaptic endings.Neurology18:
891–906
(1968)
13.
IndravasuS.DexterR.A.:
Infantile neuroaxonal dystrophy and its relationship to Hallervorden-Spatz disease.Neurology18:
693–699
(1968)
14.
IzquierdoA.E.NietoD.:
Aspectos neuropatologicos de la intoxicacion con Karwinskia humboldtiana. Estudio Experimental.Gac. Med. mex.95:163–177
(1965)
15.
LampertP.W.:
A comparative electron microscopic study of reactive, degenerating, regenerating, and dystrophic axons.J. Neuropath. exp. Neurol.26:
345–368
(1967)
16.
LampertP.BlumbergJ.M.PentschewA.:
An electron microscopic study of dystrophic axons in the gracile and cuneate nuclei of vitamin E- deficient rats.J. Neuropath. exp. Neurol.23:
60–77
(1964)
17.
MarshC.D.ClawsonA.B.RoeG.C.:
Coyotillo (Karwinskia humboldtiana) as a poisonous plant.
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McManusJ. F. A.MowryR.W.:
Staining Methods. Histologic and Histochemical
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New York1965)
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Patologia experimental y clinica de la paralisis por Karwinskia humboldtiana.Rev. Med. Ped.25:
225–237
(1956)
20.
Ramon y CajalS.:
Degenerative phenomena consequent on cerebellar traumatisms.In:
Degeneration and regeneration of the nervous system,
pp. 597–616,
Vol. 2.
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New York1959)
21.
StortsR.W.KoestnerA.:
General cultural characteristics of cerebellar explants.Amer. J. vet. Res.29:
2351–2364
(1968)
22.
SungJ.H.:
Neuroaxonal dystrophy in mucoviscidosis.J. Neuropath. exp. Neurol.23:
567–583
(1964)
23.
SungJ.H.:
Neuroaxonal dystrophy in aging.
In: Proceedings of the Fifth International Congress of Neuropathology.
pp. 478–480.
Editors: F. Luthy and A. Bischoff (Mouton, The Hague
1966)
VandermeerJ.BartoE.:
Axonal dystrophy in a deer mouse (Peromyscus maniculatus) with an inherited ataxia and tremor.J. Neuropath. exp. Neurol.28:
257–266
(1969)
