Gross and microscopic changes of the joint, heart, and brain were studied in chickens infected intravenously with M. gallisepticum (S6 isolate). Synovitis occurred within 3 days, followed by suppurative arthritis at 7 days, and osteomyelitis 5 days later. The pathologic changes were attributed to a severe vasculitis characterized by extensive fibrinoid necrosis and endothelial swelling. Ischemic change was observed in the heart and brain as a result of the acute arteritis.
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