Abstract
Rations containing up to 810 ppb aflatoxin B1 were fed to 3-month-old pigs for 107 to 117 days. Biochemical abnormalities indicative of hepatocellular damage occurred in pigs receiving 233 ppb or more aflatoxin B1. Slightly decreased gain in weight was detected in pigs fed 615 ppb aflatoxin B1, and 810 ppb resulted in reduction in efficiency of feed conversion and greatly decreased gain in weight. The livers of some pigs in the 615 and 810 ppb groups were pale yellow to tan, with increased resistance to cutting and a fine superficial granularity. Histologic lesions occurred in livers of some pigs in the 450 ppb group and in most livers of pigs in higher dosage groups. Mild changes included karyomegaly, cytoplasmic degeneration, and proliferation of bile ductules and fibrous tissue. Hepatocellular alignment into tubular structures and development of centrilobular vascular plexuses occurred in a few livers of the 810 ppb group. Only the most severely affected livers had lipidosis. There was no neoplasia.